Other

Amazon Technologies, Inc.

Construction Research & Technology Gmbh

California Institute of Technology

Pricewaterhousecoopers Llp

Azul 3d, Inc.

Technicare Corporation

Consolidated Metco Incorporated

Michael Flynn

Tadao Nakamura

Viviana Gradinaru

Lei Li

Amarsingh Buckthasingh Winston

Lars Christian Ulness

Girish Bansilal Bajaj

Michael B Elowitz

David Alan Walker

Andrew J Watts

Joshua Danovitz

Markus Bohler

Umut Utkan

Michael Baccala

Jay Valdillez

Acacia Hori

Ippei Matsumoto

Joseph G Harrington

Manish Avinash Mantrawadi

Graham Wildey

Abhishek Sanghavi

Douglas W Moskowitz

Praveen Vasireddy

Sriraj Kadimisetty

Markus Böhler

Mary England

Vinod K Kandepi

Shiva Sadula

David Tucker

Disclosed herein include methods, compositions, and kits suitable for robust and tunable control of payload gene expression. Some embodiments provide rationally designed circuits, including miRNA-level and/or protein-level incoherent feed-forward loop circuits, that maintain the expression of a payload at an efficacious level. The circuit can comprise a promoter operably linked to a polynucleotide encoding a fusion protein comprising a payload protein, a protease, and one or more self-cleaving peptide sequences. The payload protein can comprise a degron and a cut site the protease is capable of cutting to expose the degron. The circuit can comprise a promoter operably linked to a polynucleotide comprising a payload gene, a silencer effector cassette, and one or more silencer effector binding sequences.

Method for robust control of gene expression

Devices, systems, and/or methodologies are provided for three dimensional printing, for example, additive manufacturing, wherein an array of energy patterning (e.g., light patterning) modules are used in conjunction with an automated positional control system to coordinate implementation of patterning modules of the array. Implementation of the array can be controlled by a sensory feed-back.

Devices, systems, and methods for multi-projector three dimensional printing

A wearable device has a housing containing electronics and a band that retains the wearable device on a user's arm. Each end of the housing has an open receptacle. The band has protrusions made from an elastomeric material and includes a rigid member arranged at least partially within. The protrusions are inserted into the receptacle to attach the band to the housing. A lower portion of the housing comprises two pieces that, when assembled, provide optical baffles between adjacent optical devices such as a heart rate monitor, and windows for the optical devices to operate. A thermal conductor is retained between the two pieces and facilitates operation of a temperature sensor in the device. An antenna carrier facilitates installation of an antenna without impairing fixation of an upper portion of the housing. A compact charger clips to the housing to supply power to recharge a battery in the wearable device.

Wearable device with display

Techniques are described for fulfilling an utterance request for an item represented within a video rendered at a client device. In some implementations, a user account associated with the request is identified, enabling a video stream transmitted in association with the user account at the time that the request was uttered to be identified. In one technique, a timestamp associated with the request is used to identify the relevant portion of the video stream. The item represented within the portion of the video stream can be identified using various techniques and/or information such as image recognition, metadata within the video, subtitles, closed captions, and/or a database mapping between the item and a video content item transmitted in the video stream.

Utterance request of items as seen within video

Systems and methods for securely storing data for efficient access by cloud-based computing instances is provided. In one or more examples, a computing hub can receive one or more access requests to data stored within a persistent data storage computing resources that in connected to the computing hub. The computing hub can be configured to determine if the access request is from an authorized computing resource, and can then generate one or more tokens that provide access to the computing resource. The one or more tokens can include information regarding the IP address of the requesting cloud-based computing resource, and each time that the cloud-based computing resource uses the token to request access to the stored data, the computing hub can check the IP address of the computing resource against the IP address indicated on the token to decide whether or not to grant access to the data.

System and methods for securely storing data for efficient access by cloud-based computing instances

Musical instrument slide with aperture

A marching memory is disclosed having an array of memory units. Each memory unit has a sequence of bit level cells. Each bit-level cell has a transfer-transistor having a first main-electrode connected to a clock signal supply line through a first delay element, and a control-electrode connected to an output terminal of a first neighboring bit-level cell positioned at an input side of the array of the memory units, through a second delay element. Each bit-level cell also has a reset-transistor having a first main-electrode connected to a second main-electrode of the transfer-transistor, a control-electrode connected to the clock signal supply line, and a second main-electrode connected to the ground potential. Each bit-level cell also has a capacitor connected in parallel with the reset-transistor.

Marching memory, a bidirectional marching memory, a complex marching memory and a computer system, without the memory bottleneck

A marching memory includes an alternating periodic array of odd-numbered columns (U, U, . . . , U, U) and even-numbered columns (U, U, . . . , Ur, Ur). Each of the odd-numbered columns (U, U, . . . , U, U) has a sequence of front-stage cells aligned along a column direction so as to store a set of moving information of byte size or word size. And each of the even-numbered columns (U, U, . . . , Ur, Ur) has a sequence of rear-stage cells aligned along a column direction so as to store the set of moving information, so that the set of moving information can be transferred synchronously, step by step, along a direction orthogonal to the column direction.

Marching memory and computer system

Musical instrument slide with collar

Musical instrument slide with plug

A musical instrument slide for a stringed instrument and a method of manufacturing the same includes a slide body defining an outer wall, the outer wall configured to affect sound produced by the instrument when applied to one or more strings of the instrument. The slide includes an inner wall within the slide body creating a space between the slide body and the inner wall and further includes fluid, slurry or the like within the space between the slide body and the inner wall, which may further affect the sound produced by the instrument when the outer wall is applied to a string. A removable collar may be included with an aperture or opening that may vary in size to accommodate multiple users.

Musical instrument slide and method of manufacture

Growing community of inventors

Evanston, IL, United States of America

Michael Flynn