Chiron Diagnostics Corporation

Michael Flanagan

Peter G Edelman

Robert R McCaffrey

Bonnie C Dalzell

Mark W Boden

Kimiya Takeshita

Katarina Tkacik

Josef Brown

James Flaherty

Susan Holbert

An electrochemical sensor is designed for use in detecting a concentration of an analyte in a sample solution. The sensor to have a longer useful lifetime, improved stability and improved response time for single or multiple use applications. In one aspect, some of these goals are achieved by providing the multilayer enzyme electrode membrane having both nonporous and microporous layers. The microporous layer is formed from a polymer binder, a polymer powder, a surfactant and a mineral powder. In another aspect, certain of these goals are achieved by the use of a layer comprised of an enzyme disposed within a polymer matrix. In certain embodiments, the multilayer enzyme electrode membrane includes an outermost layer which is capable of dissolving in the sample solution such that the interface between the multilayer enzyme electrode membrane and the sample solution is continually renewed. The sensor provides an electrical current output proportional to the reagent chemical interaction of the analyte with an immobilized enzyme layer during exposure of the sensor in such solution.

Multilayer enzyme electrode membranes and methods of making same

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Needham, MA, United States of America

Michael Flanagan