Bruker Biospin Ag

Bruker Biospin Gmbh

Universitaet Zuerich

Michael Fey

Thomas Speck

Werner E Maas

Eckhard Bez

Kimberly Colson

Robert Krull

Don Piroli

Brian Marquez

Markus Weiger

Charles Massin

Oskar Schett

Remo Anton Hochstrasser

Kurt Himmelsbach

Konstantin Pervushin

Schimun Denoth

Peter Gor'kov

Hansjörg Tschirky

Marcel Urfer

Frank Vincent

James Masse

Sandra Loss

Till Kuehn

Bjoern Heitmann

Abraham Bernstein

Jiwen Li

Wurong Zhang

A monitoring cell, used to perform a measurement in an NMR spectrometer of a reaction fluid produced by a reaction vessel, has a body having inlet and outlet transport coaxial capillaries for transporting the reaction fluid between the body and the reaction vessel. Cooling lines are also positioned coaxially with the transport capillaries to transport cooling liquid between the body and the reaction vessel. The cell further has a hollow sample probe for insertion into the NMR spectrometer and a coupler section that removably connects the sample probe to the body so that the inlet transport capillary extends through the body into the interior of the sample probe and the outlet transport capillary is sealed to the sample probe to allow reaction fluid that enters the sample probe via the inlet transport capillary to exit the sample probe via the outlet transport capillary.

NMR reaction monitoring flow cell

A multiple resonance sample coil for a magic angle spinning nuclear magnetic resonance probe is comprised of a solenoid coil that resonates at low frequencies and a resonator that resonates at high frequencies. The ends of the low frequency solenoid coil are electrically connected to the high frequency resonator to eliminate arcing and allow the solenoid coil to extend the full width of the resonator. In some embodiments, the high frequency resonator is constructed from the outermost turns of the solenoid coil in the form of a birdcage resonator. In another embodiment, the solenoid coil is electrically connected to one turn of the resonator and the other turn is used as part of a trap to shunt the resonator at low frequencies.

Multiple resonance sample coil for magic angle spinning NMR probe

A fully automatic, parameter free MR interpretation system is based on human logic emulation. Information is derived mainly from an MR spectrum with maximum confidence and in a similar way as a human expert. This is achieved by the combination of different expert systems that interpret certain MR spectral features as well as features from a proposed structure. The expert systems are dynamically linked to each other and the analysis is performed iteratively in all directions in a way that the expert systems can utilize all of the interpretations of all expert systems at all times. The expert system may generate not just a single result but rather lists of probability weighted hypotheses.

Method and system for automated analysis of nuclear magnetic resonance spectra

A sample vessel () made of material with magnetic susceptibility &#x3c7;, for containing a sample substance () with magnetic susceptibility &#x3c7;&#x2260;&#x3c7;to be analyzed in a nuclear magnetic resonance (NMR) spectrometer, has an inner interface Gtoward the sample substance and an outer interface Gtoward the environment () that exhibits magnetic susceptibility &#x3c7;. The shape of the interface toward the sample substance and the interface toward the environment are coordinated to match the discontinuities in susceptibility at the interfaces in such a way that on introduction of the sample tube filled with sample substance into the previously homogeneous magnetic field of an NMR spectrometer, the magnetic field inside the sample substance remains largely homogeneous.

Sample holder for NMR measurements with field homogenization in the sample volume by means of the bordering surfaces of the sample holder

A flow-through microfluidic NMR-chip comprising a substrate () which is planar in an yz-plane with a sample chamber () within the substrate (), the sample chamber () being elongated and having walls which run parallel to the z-direction, the substrate () having a thickness in x-direction of a Cartesian xyz-coordinate system between 100 &#x3bc;m and 2 mm, and at least one planar receiving and/or transmission coil (') with conductor sections () the coil (&#x2032;) being arranged at least on one planar surface of the substrate (), wherein the extension of the sample chamber () along the z-direction exceeds the extension of the coil () along the z-direction is characterized in that the extension of the coil (&#x2032;) along the z-direction is larger than its extension along the y-direction. The inventive NMR-chip facilitated NMR-spectroscopic measurements with improved resolution, sensitivity as well as B1 homogeneity.

Flow-through microfluidic nuclear magnetic resonance(=NMR)-chip

A method for homogenizing a static magnetic field with a magnetic field distribution B(r) for nuclear magnetic resonance spectroscopy by adjusting the currents Cthrough the shim coils, thus creating spatial field distributions C&#xb7;S(r), where r stands for one, two, or three of the spatial dimensions x, y, and z, and said magnetic field distribution B(r) has only a field component along z, in a working volume of a magnetic resonance apparatus with one or more radio frequency (=RF) coils () for inducing RF pulses and receiving RF signals within a working volume, said RF coils having a spatial sensitivity distribution of magnitudes B(r), and with shim coils () for homogenizing the magnetic field within the working volume, said shim coils () being characterized by their magnetic field distributions per unit current S(r) and having components only along z, includes the following steps: In this way a direct one-to-one link is obtained between a set of shim currents and the associated NMR spectrum The quality of the desired NMR spectra can be improved with this method.

Method for automatic shimming for nuclear magnetic resonance spectroscopy

A nuclear magnetic resonance (NMR) probe component, comprising a microfabricated planar gradient chip (), with a substrate thickness d&#x2266;3 mm, carrying three micromachined planar partial gradient coils (-) on each of its two outer surfaces (), wherein the partial gradient coils (-) of the gradient chip () form a three-dimensional gradient system, wherein the gradient chip () has a central guiding and positioning slot () between the two outer surfaces (). The probe component also has a sample chip () for carrying an NMR sample at a sample location, with a microfabricated planar RF coil (), wherein the sample chip () fits exactly in the guiding and positioning slot () such that in a measurement position, the sample location coincides with the center of the gradient system. The NMR probe component has improved spatial resolution and allows good alignment of the RF coil and the gradient system.

NMR probe component with a gradient chip with a slot for insertion of a sample chip

A method for homogenizing a static magnetic field with a magnetic field distribution B(r) for nuclear magnetic resonance spectroscopy by adjusting the currents Cthrough the shim coils, thus creating spatial field distributions C&#xb7;S(r), where r stands for one, two, or three of the spatial dimensions x, y, and z, and said magnetic field distribution B(r) has only a field component along z, in a working volume of a magnetic resonance apparatus with one or more radio frequency (=RF) coils () for inducing RF pulses and receiving RF signals within a working volume, said RF coils having a spatial sensitivity distribution of magnitudes B(r), and with shim coils () for homogenizing the magnetic field within the working volume, said shim coils () being characterized by their magnetic field distributions per unit current S(r) and having components only along z, includes the following steps:

A nuclear magnetic resonance (NMR) spectrometer for investigating a liquid sample in a sample tube, in particular a glass sample tube (), has a sample bushing () surrounding the sample tube having a bore into which one end of the sample tube is inserted with tight fit. The sample bushing () is preferably substantially cylindrical and the bore extends along the cylindrical axis. The NMR spectrometer has a gripping device () for handling the sample bushing (), the gripping device () having at least three gripping fingers (), and the outer periphery of the sample bushing () has at least one groove () into which the gripping fingers () can engage to press onto the two outer edges of the groove () when the gripping device () is closed. The cooperation between the groove and the gripping device permits fully automated, precise handling of the samples.

NMR spectrometer with gripping device for handling a sample bushing with outer groove

A device for centering an elongated sample tube (), filled with a measuring substance, relative to a vertical axis of a nuclear magnetic resonance (NMR) receiver coil system () which is rigidly mounted in a support device is characterized in that at least two centering means are provided which are mutually separated in an axial direction of the receiver coil axis and act exclusively in a radial direction on the sample tube (), one of which is disposed in the upper region () and the other in the lower region (') of the NMR receiver coil system () and with at least one positioning means acting on the sample tube () in an exclusively axial direction which may be located either below () or above () the NMR receiver coil system, wherein the exclusively radially acting centering means (&#x2032;) are components of the NMR receiver coil system (). The centering accuracy can be increased compared to known devices to obtain optimum results even for sample tubes in the form of measuring capillaries which pose the highest requirements with respect to centering accuracy.

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Hornussen, Switzerland

Michael Fey