Diversatek Healthcare, Inc.

Vanderbilt University

Michael F Vaezi

Thomas D Stuebe

Jerry E Mabary

Charles L Lindsay

James M Prinster

A mucosal impedance measuring apparatus detects and measures a condition of mucosa. The mucosal impedance measuring apparatus includes a catheter comprising a tube, impedance sensing electrodes on an exterior surface of the catheter, a balloon mounted on the tube in which the balloon is capable of inflation and deflation, and an impedance measuring system. The impedance measuring system is adapted to measure a pressure-regulated impedance measurement of the mucosa that is indicative of the condition of the mucosa when the balloon is inflated and the impedance sensing electrodes direct an electric current through mucosa while the balloon is pressed against the mucosa.

Mucosal impedance measuring apparatus for detecting and measuring the condition of mucosa

Disclosed are catheter systems and methods of using the catheter system to acquire mucosal impedance data of a patient. Also disclosed are methods of classifying or otherwise identifying esophageal conditions in a subject based on mucosal impedance data acquired using a catheter system. Unlike conventions systems that require subjective input from a physician to render a diagnosis, the systems and methods described herein can utilize the mucosal impedance measurements to generate a probability that the subject's esophagus corresponds to an esophageal condition or a set of esophageal conditions. In one embodiment, a classification model is used to generate the probability. The classification model may generate the probability based at least in part on a change in the mucosal impedance measurements between a distal location and a proximal location on the subject's esophagus.

System and method for detecting and measuring the condition of intraluminal esophageal mucosa

A method of detecting and measuring the condition of intraluminal esophageal mucosa. An esophagus is intubated with a catheter including an inflatable and deflatable balloon and one or more impedance sensing electrodes on an exterior surface of the catheter. The balloon is inflated to press the impedance sensing electrode(s) into a mucosa of the interior esophageal wall. An electric current is directed through the mucosa via the impedance sensing electrode(s) while the impedance sensing electrode(s) is/are pressed by the balloon against the mucosa and measure impedance of the mucosa.

Method of detecting and measuring the condition of intraluminal esophageal mucosa

A mucosal impedance measuring system that is capable of direct and accurate impedance measurements of esophageal mucosa includes example multi-channel intraluminal impedance catheters with inflatable and deflatable components for positioning the impedance sensor electrodes in direct contact with the esophageal mucosa on the inside surface of the esophagus. Impedance measurements from multiple locations in the esophagus are processed for indications of mucosal damage that are indicative of damage due to gastrointestinal reflux disease (GERD), non-erosive reflux disease (NERD), and Barrett's esophagus.

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Brentwood, TN, United States of America

Michael F Vaezi