G.d. Searle & Company

Michael F Rafferty

Barnett S Pitzele

Michael S Dappen

Timothy J Hagen

E Ann Hallinan

Robert K Husa

Michael John Clare

Claude L Gillet

Joseph L Roba

Bevyn Jarrott

Philip Mark Beart

Use of heterocyclic amino-alcohol compounds for treatment of CNS diseases

The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

1-,2-,3-,4-,5-,6-,7-,8-, and/or 9-substituted dibenzoxazepine compounds,

The present invention provides novel substituted opioid analgesic compounds of Formula I: ##STR1## which are opioid agonists, and which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

Opioid agonist compounds

2-, 3-, 5-, 8-, 10- and/or 11-substituted dibenzoxazepine compounds,

1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds,

The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are opioid agonists which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

The present invention provides a method for eliminating or ameliorating pain in an animal comprising administrating a therapeutically-effective amount of a substituted morphinoid compound of Formula I: ##STR1## The compounds are opioid agonists which are useful as analgesic agents for the treatment of pain.

Method of using opioid compounds as delta opioid selective agonist

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Buffalo Grove, IL, United States of America

Michael F Rafferty