Aventis Pharma Deutschland, Gmbh

Sanofi-A Ventis Deutschland Gmbh

Michael F Kelley

Robert D Groneberg

Daniel Gerard McGarry

Anne Minnich

Gerard M McGeehan

Zaid Jayyosi

Richard F Labaudiniere

Mark A Bobko

Litao Zhang

Robert L Morris

Thomas Caulfield

Mark Bobko

Thomas J Caulfield

The use of diaryl acid derivatives of formula (I)or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.

Therapeutic uses of di-aryl acid derivatives

The use of triaryl acid derivatives of formula (I)and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.

Therapeutic uses of tri-aryl acid derivatives

A method for mediating the activity of PPAR-&ggr; receptor comprising contacting said PPAR-&ggr; receptor with a compound of formula I defined herein. Also disclosed is the treatment of a patient suffering from a physiological disorder capable of being modulated by a compound of formula I having PPAR-&ggr; ligand binding activity, comprising administering to the patient a pharmaceutically acceptable amount of the compound, or a pharmaceutically acceptable salt thereof.

Therapeutic uses of quinoline derivatives

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West Chester, PA, United States of America

Michael F Kelley