Other

Boston University

The General Hospital Corporation

Massachusetts General Hospital Corporation

A & D Bioscience, Inc.

Hoffmann-la Roche Inc.

Strakan Limited

A and D Assay, Incorporated

Michael F Holick

Rahul Ray

Sally A Holick

Xiao Q Tian

Milan R Uskokovic

Julia McLaughlin

John Kanis

Zhiren Lu

Halasya Ramanathan

Lawrence Gilbert

Brian De Costa

The invention features methods for the treatment of vaginal atrophy by administering a parathyroid hormone peptide or peptide analog and formulations thereof.

Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy

Disclosed are glycosides, orthoester glycosides and glycuronamides of fluoxetine and analogs thereof to treat conditions and diseases such as depression.

Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof

Androgen glycosides provide free, circulatory androgen on oral administration as they are subject to less, first pass breakdown by the liver.

Androgen derivatives and uses thereof

Biotin, fluorescent and chemiluminescent labeled vitamin D compounds are disclosed as well as their use in assays for the presence of vitamin D, its metabolites and vitamin D analogs in biological fluids.

Labeled vitamin D compounds and the use thereof

Kit comprising biotin, fluorescent and chemiluminescent labeled vitamin D compounds are disclosed. The disclosed kit may be used in assays for the presence of vitamin D, its metabolites and vitamin D analogs in biological fluids.

Kits comprising labeled vitamin D compounds

Disclosed are methods of inhibiting proliferation and enhancing differentiation of a mammalian cell, inducing proliferation of a mammalian cell, enhancing wound healing, and stimulating hair growth using a peptide which has a 10% or greater homology to a region of human parathryoid hormone or human hypercalcemic factor.

Regulation of cell proliferation and differentiation using peptides

The present invention is directed to the discovery that topical or parenteral administration of emu oil to a mammal stimulates the proliferation of skin. Emu oil can be used to treat skin wrinkles and rejuvenate aged and photo-damaged skin. It has also been discovered that emu oil can be topically applied to stimulate melanogenesis in the skin and to stimulate hair growth. Thus, emu oil is useful to treat pigmentation disorders such as hypopigmentation, stimulating melanogenesis to enhance skin tanning, and treating disorders relating to disturbances in hair cycling such as alopecia, male pattern baldness, female baldness, and chemotherapy-induced alopecia.

Use of emu oil for stimulating skin and hair growth

Disclosed are methods of inhibiting proliferation and enhancing differentiation of a mammalian cell, inducing proliferation of a mammalian cell, enhancing wound healing, and stimulating hair growth using a peptide which has 10% or greater homology to a region of human parathyroid hormone or human hypercalcemic factor.

Regulation of cell proliferation and differentation using peptides

The present invention relates to methods for the treatment or prevention of osteoporosis and the alleviation of the symptoms of menopause by the administration of an estrogen glycoside or estrogen orthoester glycoside.

Method for delivering estrogen

The present invention relates to methods for the treatment of prevention of osteoporosis by the administration of a vitamin D glycoside or vitamin D orthoester glycoside, or an analog thereof.

Use of vitamin D glycosides, vitamin D orthoester glycosides, vitamin D

Methods for enhancing the ability of an individual, exposed to sunlight, to produce vitamin D via the skin. Pharmaceutical compositions comprising lumisterol and/or tachysterol are also disclosed.

Growing community of inventors

Sudbury, MA, United States of America

Michael F Holick