Icagen, Inc.

Bristol-myers Squibb Compnay

Other

Eli Lilly and Company

Icafen, Inc.

Michael F Gross

Serge Beaudoin

John E Lloyd

Heather J Finlay

Grant Andrew McNaughton-Smith

Alan David Wickenden

Aimee Dolores Reed

Karnail S Atwal

Wayne D Vaccaro

Kerry Leigh Spear

Robert N Atkinson

Lin Yan

Yoon T Jeon

Jose Serafin Mendoza

Neil A Castle

Albert Michiel Van Rhee

Philip Floyd Hughes

Sean Patrick Hollinshead

George Salvatore Amato

Joseph Wendell Wilson

Gregory Cooksey Rigdon

Matthew Scott Johnson

Neil Alexander Castle

Anrou Zou

A trim installation tool, attachable to the jamb of a window or door, which aids in the installation of trim. The tool provides for the marking of a consistent reveal around a door or window when installing trim. The tool also provides a surface which may be used to provide support to the end of a tape measure when performing measurements. Additionally, the tool may provide support for the trim being installed around the door or window.

Trim installation tool

Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the K1 subfamily of voltage gated Kchannels, especially inhibitors K1.5 which has been linked to the ultra-rapidly activating delayed rectifier Kcurrent I), methods of using such compounds in the prevention and treatment of arrhythmia and I-associated conditions, and pharmaceutical compositions containing such compounds.

Heterocyclo inhibitors of potassium channel function

Compounds useful as prodrugs of potassium channel inhibitor compounds, in particular as prodrugs of Kv1.5 channel inhibitors.

Prodrugs of potassium channel inhibitors

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

Piperidines

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

Pyrazole-amides and -sulfonamides

Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K1 subfamily of voltage gated Kchannels, especially inhibitors K1.5 which has been linked to the ultra-rapidly activating delayed rectifier Kcurrent I), methods of using such compounds in the prevention and treatment of arrhythmia and I-associated conditions, and pharmaceutical compositions containing such compounds.

Cycloalkyl inhibitors of potassium channel function

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

Pyrazolopyrimidine compositions

Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.

Benzanilides as potassium channel openers

Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure:where A, B, D, Q, X, R, R, Xand Rare as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.

Potassium channel inhibitors and method

Compounds as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.

Potassium channel inhibitors

Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.

Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.

Growing community of inventors

Durham, NC, United States of America

Michael F Gross