Bristol-myers Squibb Compnay

Michael F Dee

John E Macor

Jianliang Shi

Lorin A Thompson, Iii

F Christopher Zusi

There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, and Ras defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by &#x3b2;-secretase and, more specifically, inhibit the production of&#x3b2;-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to &#x3b2;-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

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Madison, CT, United States of America

Michael F Dee