General Electric Company

Other

Michael Ernest Marino

Jeffrey Michael Ashe

Christopher Michael Puleo

Robert Edgar Colborn

Matthew David Butts

Andrew Soliz Torres

Victoria Eugenia Cotero

Bruce Allan Hay

Alberto Santamaria-Pang

Faisal Ahmed Syud

Brian Christopher Bales

Elin Gunneriusson

Peter John Bonitatibus, Jr

Dmitry Vladimirovich Dylov

Brian Duh-Lan Lee

Malin Lindborg

Qing Li

Amit Mohan Kulkarni

Daniel Eugene Meyer

Anup Sood

Amit Kulkarni

Michael John Gerdes

Rong Zhang

Christofer Lendel

Fiona Ginty

Jason William Castle

Paul Schaffer

Christopher James Sevinsky

Yunxia Sui

Aritra Chowdhury

Joseph Schorn

Christopher Lendel

Peter John Bonitatibus Jr

Brian C Bales

The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation.

Techniques for neuromodulation

The present approach relates to the use of trained artificial neural networks, such as convolutional neural networks, to classify vascular structures, such as using a hierarchical classification scheme. In certain approaches, the artificial neural network is trained using training data that is all or partly derived from synthetic vascular representations.

Methods of systems of generating virtual multi-dimensional models using image analysis

The subject matter of the present disclosure generally relates to techniques for image analysis. In certain embodiments, various morphological or intensity-based features as well as different thresholding approaches may be used to segment the subpopulation of interest and classify object in the images.

Systems and methods for automatic generation of training sets for machine interpretation of images

A paddle for a watercraft or flotation device has a pair of shaft mounted blades connected by a core member. A right hand drive grip and a left hand drive grip are secured in spaced relation to opposite ends of the core. A right hand offset is mounted adjacent the right hand drive grip and a left hand offset is mounted adjacent the left hand drive grip for providing hand clearance for a user. The core is telescopically expandable and accommodates various size paddle shafts for propelling different watercraft.

Paddle for watercraft or flotation device

Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

Nanoparticle contrast agents for diagnostic imaging

Provided herein are methods of reducing liver uptake in vivo of a polypeptide that specifically binds to a target comprising: (a) providing a polypeptide that specifically binds to a target; and (b) substituting at least one basic or at least one neutral amino acid residue of the native polypeptide from step (a) with an acidic amino acid residue to produce a modified polypeptide, wherein the modified polypeptide demonstrates an isoelectric point at least 0.05-0.1 pH points less than the isoelectric point of the native polypeptide. Also provided are polypeptides made using the inventive methods as well as imaging techniques that employ the methods and agents.

Biokinetics of fast-clearing polypeptides

Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.

Provided herein are PDGF-R&#x3b2; imaging agents that are polypeptides labeled with a signal generator (e.g., paramagnetic label, a radionuclide, or a fluorophore), wherein the imaging agents bind specifically to PDGFR-&#x3b2;. Also provided are in vivo imaging methods using the imaging agents.

PDGF-R&#x3b2; binders

Growing community of inventors

Clifton Park, NY, United States of America

Michael Ernest Marino