Boston Scientific Scimed, Inc.

Mayo Foundation for Medical Education and Research

Michael Eppihimer

David R Wulfman

Peter G Edelman

Crystal Marie Anderson-Cunanan

Aiden Flanagan

Bryan Allen Clark

Mark W Boden

Joseph T Delaney, Jr

Juan Gabriel Hincapie Ordonez

Patrick Willoughby

William Conrad Stoffregen

Thomas A Wrobel

James P Rohl

Devon N Arnholt

Mary M Byron

James K Cawthra, Jr

Joseph A Dearani

David J Lehse

Katherine Lorraine Baldwin

Peter M Pollak

Katherine Cora Fazackerley

Shannon Smith Kenwood

Natalia P Sushkova

Karen Suzanne Lavery

David Robert Wulfman

Jr Joseph Thomas Delaney

Jr James K Cawthra

A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.

Prosthetic heart valves having fiber reinforced leaflets

A heart valve anchor has a body that includes a distal portion, a distal end, a proximal portion, and a proximal end. The distal end and the proximal end define a longitudinal axis. The body has an expandable portion that includes a first radially expandable portion at the distal portion of the body, a second radially expandable portion at the proximal portion of the body, and a root portion disposed between the first and second radially expandable portions. The body has a first configuration adapted to be housed at least partially within a tissue penetrating device, and a second configuration in which the first and second radially expandable portions are partially or fully expanded such that the anchor engages tissue in a region between the first and second radially expandable portions.

Heart tissue anchors

A prosthetic heart leaflet includes a fiber-reinforced structure including a plurality of composite fibers. Each composite fiber includes a core fiber and a sheathing fiber disposed about the core fiber, wherein the core fiber or the sheathing fiber has a curvilinear shape.

Prosthetic heart valve composed of composite fibers

A prosthetic heart valve provided herein can include a cultured cell tissue leaflet. In some cases, a prosthetic heart valve can include a plurality of leaflets secured together and retained within the expandable tubular member. The cultured cell tissue can be obtained by culturing fibroblast cells, smooth muscle cells, or a combination thereof to form a sheet of cultured cells and chemically cross-linking the fibroblast cells while under tension. In some cases, the cultured cell tissue can be radially tensioned. In some cases, the cultured cell tissue can be bi-axially tensioned.

Cultured cell leaflet material

A medical device may include a stimulation member configured to apply a stimulus to a nerve that is configured to control a contraction of an airway distal to the nerve, and a measurement member configured to measure an effect of the stimulus on the airway. The medical device also may include an energy delivery element configured to deliver energy to tissue defining the airway to reduce an effect of the stimulus on the airway. The energy delivery element may be disposed at or distally of the stimulation member.

Diagnosis and treatment devices and related methods of use

Airway diagnosis and treatment devices and related methods of use

Growing community of inventors

Franklin, MA, United States of America

Michael Eppihimer