University of Pennsylvania

Celldex Therapeutics Limited

Celldex Research Corporation

Michael Endres

Tibor P Keler

Yashwant M Deo

James A Hoxie

Robert Doms

John Treml

Trevor L Hoffman

Joseph B Rucker

Paul Bates

John Balliet

Dennis L Kolson

Lizhen He

Venky Ramakrishna

The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (&#x3b2;hCG) antigen linked to an anti-mannose receptor (MR) antibody.

Antibody vaccine conjugates and uses therefor

Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to dendritic cells are disclosed. Also disclosed are bispecifics, immunotoxins and antigen conjugates which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

Monoclonal antibodies to dendritic cells

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

Method for the production of antibodies that bind to multiple membrane spanning proteins

Method for the preparation of virus-like particles (VLPS) comprising heterologous multiple membrane spanning proteins

The present invention provides novel methods for targeting an antigen to a dendritic cell using an antibody linked to the antigen. The present invention further provides methods of inducing or enhancing an immune response and methods of immunization using an antibody linked to the antigen.

Methods of using molecular conjugates comprising monoclonal antibodies to dendritic cells

Virus-like particles (VLPs) comprising heterologous multiple membrane spanning proteins

Molecular conjugates comprising an antigen linked to a human monoclonal antibody that specifically binds to dendritic cells are disclosed. Also disclosed are pharmaceutical compositions comprising the molecular conjugates and therapeutic methods for using the conjugates.

Molecular conjugates comprising human monoclonal antibodies to dendritic cells

Growing community of inventors

Painesville, OH, United States of America

Michael Endres