Xenon Pharmaceuticals Inc.

Genentech, Inc.

Zalicus Pharmaceuticals, Ltd.

Michael Edward Grimwood

Christoph Martin Dehnhardt

Thilo Focken

Sultan Chowdhury

Alla Yurevna Zenova

Ivan William Hemeon

Jean-Christophe Andrez

Shaoyi Sun

Qi Jia

Brian Salvatore Safina

Michael Scott Wilson

Daniel P Sutherlin

Kristen Nicole Burford

Paul Robert Bichler

Daniel Fred Ortwine

Philippe Bergeron

Shannon Marie Decker

Abid Hasan

Syed Abid Hasan

Robert Joseph Devita

Tao Sheng

Wei Gong

James Philip Johnson, Jr

James Roy Empfield

Charles Jay Cohen

Jun M Li

Steven Sigmund Wesolowski

Steven McKerrall

Zhiguo Liu

Verner Alexander Lofstrand

Jiuxiang Zhu

Andrew D White

Chien-An Chen

Tao Wang

Yuanxi Zhou

Jianmin Fu

David Earl Bogucki

Tarek Suhayl Mansour

Nagasree Chakka

Hassan Pajouhesh

Yongbao Zhu

Yanbing Ding

Kwong Wah Lai

Ramesh Kaul

Lingyun Zhang

Jason Tan

Teresa Phuongtram Nguyen

James Philip Johnson

Jun Li

Jr Johnson James Philip

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

Benzenesulfonamide compounds and their use as therapeutic agents

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

Benzenesulfonamide compouds and their use as therapeutic agents

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

The invention provides a compound of formula: or a salt thereof, wherein the variables R, n, ring A, ring B, R, R, R, R, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

This invention is directed to heteroaryl-substituted sulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors

This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X, L, subscript m, X, ring D, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

N-substituted benzamides and methods of use thereof

Growing community of inventors

Burnaby, Canada

Michael Edward Grimwood