Ge Healthcare Bio-sciences Corp.

Global Life Sciences Solutions USA LLC

Hubbell Limited

Xcellerex, Inc.

Other

Global Life Sciences USA LLC

Synvasive Technology, Inc.

Michael Edward Fisher

Parrish M Galliher

Geoffrey L Hodge

Richard Lee Damren

Thomas John Erdenberger

Colin R Tuohey

Patrick M Guertin

Jonathan A Kenney

Joseph D Crowell

Dan Mardirosian

Robert Wilton Fox

Gregory Glenn Isaacson

Wiley Richard Tipton

John Thomas Polk

Jeffery Scott Huffstetler

John Swibes

Colin Touhey

Laura E Niklason

Kenneth Dale Johannaber

Anthony K Hedley

Russell Todd Nevins

Patric Fricking

Justin T Strader

Barjinder S Chana

William E Tente

Shannon Dahl

Kenneth P Clapp

Joseph Makowiecki

Juliana Blum

John Unger

Ryan Hudlow

John J Vicalvi

Paul Steven Tramm

Scott A Mangiacotti

Greg Glenn Isaacson

Samuel Theophilis Johnson

Joseph J Arduino

Ted Deloggio

Jiyoung Lee

Charles R Cramer, Jr

Brianna Joelle Vanderveen

Wiley Rick Tipton

Patrick Guertin

A bioreactor configured to contain a volume of liquid is provided. The bioreactor includes a collapsible bag able to contain the volume of liquid, a first sparger connected to the collapsible bag, and a second sparger connected to the collapsible bag.

Method of forming a collapsible bag using a mold and mandrel

Enclosure covers for use with direct burial enclosures are provided. The enclosure covers includes a latch assembly that permits the enclosure cover to automatically lock to an enclosure box when installed.

Latch locking cover for enclosures

Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.

Continuous recovery harvest bag

Systems and methods for containing and manipulating liquids, including vessels and unit operations or components of cell culture, cell containment, bioreactor, and/or pharmaceutical manufacturing systems. In certain embodiments, such vessels and unit operations are directed to continuous perfusion reactor or bioreactor systems and may include one or more disposable components. In one aspect, a system includes an apparatus in the form of a bioreactor for harvesting cells. The apparatus may include a disposable, collapsible bag for containing a liquid, the collapsible bag in fluid communication with a liquid-solids separation device. An outlet of the collapsible bag may be connected to an inlet of the separation device, and an outlet of the separation device may be connected to an inlet of the collapsible bag. After separating the cells from the liquid in the separation device, the cells can flow back into the collapsible bag for re-harvesting.

Continuous perfusion bioreactor system

A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.

Probe assembly

A bioreactor configured to contain a volume of liquid is provided. The bioreactor includes a collapsible bag able to contain the volume of liquid, a support structure surrounding and containing the collapsible bag, a first sparger connected to the collapsible bag, the first sparger having a first aperture size, and a second sparger connected to the collapsible bag, the second sparger having a second aperture size that is different from the first aperture size.

Precast utility enclosure aprons for buried utility enclosures that have an angled top surface to direct water, ice and debris away from the center of the apron and to limit damage to the apron and utility enclosure caused by impacts to the apron.

Utility enclosure apron

Systems and methods for containing and manipulating liquids, including vessels and unit operations or components of cell culture, cell containment, bioreactor, and/or pharmaceutical manufacturing systems, are provided. The apparatus may include a disposable, collapsible bag adapted for containing a liquid, the collapsible bag in fluid communication with a liquid-solids (e.g., cell) separation device. For example, an outlet of the collapsible bag may be connected to an inlet of the separation device, and an outlet of the separation device may be connected to an inlet of the collapsible bag for recycle. Accordingly, after separating the cells from the liquid in the separation device, the cells can be flowed back into the collapsible bag where they can be re-harvested. Meanwhile, product contained in the liquid can be collected in a separate container. The efficiency of product formation in such a system may be enhanced by using mixing systems described herein.

A vessel configured to contain a liquid is provided. The vessel includes a collapsible bad, a reusable support structure, a sensor, and a controller. The collapsible bag is operative to contain the liquid. The reusable support structure is operative to support the collapsible bag. The sensor is operative to measure a parameter within the collapsible bag. The controller is in electronic communication with the sensor and operative to introduce an antifoaming agent into the collapsible bag based at least in part on a signal received from the sensor.

A light base configured to be installed in the ground and to receive a light fixture to be mounted thereon, comprises a hollow body member having a first end, a second end opposite the first end, and an interior region between the first and second ends. The first end includes a first opening which is in communication with the interior region and which is configured to receive a light fixture. The hollow body member is formed of a polymer concrete material.

Light base

The present disclosure provides an underground cable enclosure having a body made of a composite material, and a cover assembly having at least one cover rail that is made of polymer cement and molded to at least a portion of the body, and at least one cover that is made of polymer cement and can rest on the at least one cover rail.

Underground composite cable enclosure

A utility enclosure includes a box, a bracket connected to the box, and a lid placed over the box. The box includes a plurality of walls and a central opening. The bracket has a center portion and a first opening in the center portion for receiving a fastener to connect the bracket to one of the walls. The removable lid covers the central opening.

Anti-theft enclosure and cover

Growing community of inventors

Knoxville, TN, United States of America

Michael Edward Fisher