Koninklijke Philips Corporation N.v.

Westinghouse Electric Corporation

Ric Investments, Inc.

Koninklijke Philips Electronics N.v.

Michael Edward Colbaugh

Erik Kurt Witt

Douglas M Mechlenburg

William Edwin Clegg

Benjamin Alfred Giovannelli

Kevin Wells

Zachary Dean Paul

Surya Subrahmanya Sreeram Vissapragada Venkata Satya

Stefanie Lattner

Michael Cessna

Maarten Leonardus Christian Brand

Todd Kirby

Lauren Elizabeth Hueser

William H Broadley

Vijay Kumar Iyer

Al Vangura

Peter Chi Fai Ho

Wei Zhou

Juris A Asars

Leonardo Alberto Baloa Welzien

John J Wilhelm

Steven B Radney

Christopher Scott Lucci

Boomika Kalyan

Mark DiMatteo

Edmund Arnliot Shaw

Stefanida K Blake

Theodore J Batt

Andreas Ralph Maihoefer

James Garsteck

Mark Toddman Kirby

Patrick Devinney

Nathan Zimmerman

Xia Chen

Rodney N Zeigler

Timothy A Nathan

Ronald Dean Dean Fligge

Stefanida Kononov Blake

Mark Anthony Bartolomeo

Eric Kurt Witt

This disclosure pertains to a system configured to control light exposure for circadian phase management and/or light deficient disorders of a subject. The system comprises a user interface, physiological sensors configured to generate output signals conveying physiological data of the subject, and a light control valve configured to block or reduce blue light ambient radiation reaching eyes of the subject. Processors are in communication with the user interface, the physiological sensors, the light control valve, and radiation generators. The processors cause the system to receive physiological goals of the subject, determine a light control plan based on the physiological goals, the physiological data, environmental data, and time data. The system operates the light control valve to block or reduce blue light ambient radiation based on the light control plan, and generate, using the one or more radiation generators, therapeutic light radiation based on the light control plan.

Controlling light exposure for circadian phase management

Systems and methods for classifying breathing disorders of subjects are based on the respiratory response to a change in a pressure level of a pressurized flow of breathable gas. The change presents a breathing challenge to a subject. The challenge may be limited to the inspiratory breathing phase. The inspiratory pressure level may be lower than the expiratory pressure level during challenges.

Reverse dual positive airway pressure challenges for breathing disorder diagnostics

The present system () comprises a subject interface (), a segmenter (), a loosener (), sensors (), and computer processors (). The segmenter is configured to selectively control gas flow through the subject interface to provide high amplitude pressure oscillations () during exhalation such that the high amplitude pressure oscillations aid cough productivity in the subject. The loosener controls gas flow through the subject interface to provide low amplitude pressure oscillations () during inhalation () and exhalation () such that the low amplitude pressure oscillations loosen respiratory secretions. The computer processors detect trigger events based on the output signals such that the one or more trigger events include a loosening trigger event and a segmenting trigger event (); and responsive to detecting the loosening trigger event, control the loosener to provide the low amplitude pressure oscillations, and, responsive to detecting the segmenting trigger event, control the segmenter to provide the high amplitude pressure oscillations.

Secretion loosening and cough segmenting therapy

A system and method configured to control pressure during enhanced cough flow of a subject are provided. A pressure regulator is operated such that during an individual exhalation of the subject, the pressure regulator is toggled between a first mode in which a subject interface is closed such that substantially no gas is communicated with the airway of the subject there through and a second mode in which the subject interface is opened to cause a series of exsufflation events for the individual exhalation of the subject. The pressure relief valve is associated with the subject interface and configured to open and release gas out of the subject interface, responsive to pressure within the subject interface exceeding a predetermined threshold value so as to maintain the pressure within the subject interface within a predetermined pressure range during the enhanced cough flow.

Controlling pressure during enhanced cough flow

A respiration appliance, system, and method for supporting the airway of a subject as the subject breaths. The flow of gas from the lungs of the subject during exhalation is leveraged to provide support to the airway. In particular, a body that encloses one or more external orifices of the subject provides a resistance differential between inhaled gas flows and exhaled gas flows that supports the subject's airway.

System and respiration appliance for supporting the airway of a subject

Light therapy is provided to a subject using a system and/or method. The light therapy includes the administration of electromagnetic radiation to the eyeball of the subject underneath the eyelid of the subject while the eyelid of the subject is closed (e.g., as the subject sleeps). The light therapy algorithm may be designed to impact melatonin and/or serotonin levels within the body of the subject in a therapeutically beneficial manner. For example, the light therapy algorithm may be designed to impact melatonin and/or serotonin levels to treat one or more of a sleep and/or mood disorder (e.g., seasonal affective disorder, non-seasonal depression, Circadian rhythm disruption), or other disorders treatable with control over melatonin and/or serotonin levels in the body.

System and method for delivering electromagnetic radiation to the eyeball of a subject

Light therapy is provided to a subject through a sleep mask. The sleep mask is configured to deliver electromagnetic radiation to the closed eyelids of the subject within two separate wavelength bands. The first wavelength band is therapeutically impactful in adjusting the sleep cycle of the subject. The second wavelength band preconditions the subject for delivery of the electro-magnetic radiation in the first wavelength band, maintains the apparent brightness of the electromagnetic radiation throughout therapy, enables cooling within the sleep mask, enhances the power efficiency of the sleep mask, and/or provides other benefits. The first wavelength band and the second wavelength band are selected based on attenuation of electromagnetic radiation by the eyelid of the subject.

System and method for providing light therapy to a subject using two or more wavelength bands of electromagnetic radiation

An apparatus for use in diagnosing the presence of obstructive sleep apnea (OSA) in a patient includes a sensing module structured to measure a parameter indicative of a tremor in the patient's neck, tongue and/or throat muscles while the patient is awake, the parameter not being airflow through the patient's airway. The sensing module generates one or more electrical signals based on the measured parameter. The apparatus also includes a processor operatively coupled to the sensing module, the processor being structured to receive the one or more electrical signals, perform an analysis of the one or more electrical signals, and based on the analysis determine whether the tremor has a frequency in at least one predetermined frequency range that is indicative of OSA.

Method and apparatus for diagnosing obstructive sleep apnea with an awake patient

A vestibular stimulation system and method that includes a housing, a power supply disposed in the housing, an electrode assembly adapted to be coupled to the housing, and a controller disposed in the housing and operatively coupled to the power supply. The controller controls the delivery of energy from the power supply to the electrode assembly. An input element is also disposed on an exterior surface of the housing. The input element is manually manipulated to control the operation of the vestibular stimulation system. A display disposed on an exterior surface of the housing provides visual information regarding the operation of the vestibular stimulation system. A mounting assembly is coupled to the housing to mount the housing on such a user.

Vestibular stimulation system

Methods and system of respiratory therapy treat sleep apnea by particular elevated pressure levels during the end of exhalation phases. Inhalation pressure levels may thus be significantly reduced and be, on average, lower than the exhalation pressure levels.

System and method for limited flow respiratory therapy

A respiratory interface apparatus () is provided that includes a patient contacting portion () structured to engage a face of the patient, a common chamber () fluidly coupled to the patient contacting portion (), a first control chamber (), a first flow regulating mechanism () provided between the first control chamber () and the common chamber (), a second control chamber (), and a second flow regulating mechanism () provided between the second control chamber () and the common chamber ().

Respiratory interface apparatus

A respiration appliance () is configured to entrain the breathing of the subject. The breathing of the subject is entrained to modulate the autonomic nervous system of the subject to decrease sympathetic nerve activity and/or to reduce sympathetic/parasympathetic balance in order to provide relaxation to the subject. The respiration appliance () restricts the exhalation of the subject, while permitting substantially unencumbered inhalation, to impact the breathing of the subject in a manner that enhances relaxation.

System and method for entraining the breathing of a subject

Light therapy is provided to a subject through a sleep mask. The sleep mask is configured to deliver electromagnetic radiation to the closed eyelids of the subject within a defined optimal wavelength band that is therapeutically impactful in modulating circadian and related systems of the subject.

Efficient circadian and related system modulation with a sleep mask

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Level Green, PA, United States of America

Michael Edward Colbaugh