University of California

Michael E Todhunter

Zev Jordan Gartner

Noel Youngho Jee

Jennifer S Liu

Robert Joseph Weber

Nicholas Scott Selden

Samantha Isabel Liang

Disclosed are membrane-anchored polynucleotides, and compositions comprising the membrane-anchored polynucleotides. Also disclosed are the processes for the synthesis of these compounds, compositions comprising such compounds, and the use of such compounds and compositions in research and therapeutic applications.

Reprogramming of cellular adhesion

The present disclosure provides methods of patterning cells on a surface of a substrate. The methods include disposing a pattern of nucleic acids on a surface of a substrate, and contacting the patterned nucleic acids under hybridization conditions with a first suspension of cells, where cells of the first suspension include cell surface-attached nucleic acids complementary to the patterned nucleic acids, and where the cell surface-attached nucleic acids hybridize to the patterned nucleic acids to pattern the cells on the surface of the substrate. Systems and kits for practicing the methods are also provided.

Methods of patterning cells on a surface of a substrate and programmed assembly of three-dimensional living tissues

Growing community of inventors

San Francisco, CA, United States of America

Michael E Todhunter