Sam Technology, Inc.

Michael E Smith

Alan S Gevins

Harrison Leong

Isabel Sam-Vargas

An efficient, objective testing method and system for evaluating changes in mental function is described. The method and system are based on measuring an individual's behavioral responses and brain function during a brief cognitive test battery and passive control conditions. The method and system is designed to assess an individual's fundamental cognitive functions, and whether those functions have been significantly affected by a variety of factors such as progressive disease processes, medication, stress, fatigue, training, or the passage of time. The method and system can be used to determine whether drugs being evaluated to treat diseases or conditions affecting cognitive brain function have a significant positive effect on delaying or improving the symptoms of such a disease or condition, especially during clinical trials for drug approval and subsequent marketing. The method and system may also be employed as part of the successful diagnosis or ongoing treatment of neurological diseases or conditions that directly or indirectly affect human neurocognitive performance. The method and system may also be used to determine transitory changes in overall cognitive function due to emotional stress or fatigue, and more long lasting changes in overall cognitive function following training and educational programs.

Neurocognitive function EEG measurement method and system

An efficient, objective testing method and system for evaluating mental acuity and changes in mental acuity is described. The method and system are based on measuring an individual's behavioral responses and brain function during a brief test of working memory and passive control condition. The method and system is designed to assess an individual's overall cognitive ability (&ldquo;general intelligence&rdquo;), and whether that overall cognitive ability has been significantly affected by a variety of factors such as progressive disease processes, medication, stress, fatigue or training. The method and system can be used to determine whether drugs being evaluated to treat diseases or conditions affecting higher cognitive brain function have a significant positive effect on delaying or improving the symptoms of such a disease or condition, especially during clinical trials for drug approval and subsequent marketing. The method and system may also be employed as part of the successful diagnosis or ongoing treatment of neurological diseases or conditions that directly or indirectly affect human neurocognitive performance. The method and system may also be used to determine transitory changes in overall cognitive ability due to emotional stress or fatigue, and more long lasting changes in overall cognitive ability following training and educational programs.

Neurocognitive ability EEG measurement method and system

A computer-aided training system uses electroencephalograms (EEGs) recorded from the trainee's scalp to alter the training protocol being presented by the computer, for example to present a new task to the trainee when he or she has mastered and automatized the current task. The index of the trainee's skill mastery and automatization is determined by analysis of the EEG using mathematical classification functions which distinguish different levels of skill acquisition. The functions are computed by computer neural networks and consist of a combination of EEG and other physiological variables which specifically characterize a trainee's level of focused attention and neurocognitive workload and his or her neurocognitive strategy. The functions are derived either for a group of trainees, or each trainee individually, performing a battery of one or more standard training tasks while wearing an EEG hat.

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San Francisco, CA, United States of America

Michael E Smith