Battelle Pulmonary Therapeutics, Inc.

Battellepharma, Inc.

Battelle Memorial Institute

Zivena, Inc.

Michael E Placke

Anthony Rocco Imondi

Michael J Brooker

Praful K Shah

John E Frye

William C Zimlich

Michael B Mosholder

Paul T Kotnik

James D Browning

Rachel Thurston

Douglas R Flanagan

Maureen D Donovan

A pulmonary dosing system and method for supplying to a patient a predetermined amount of respirable therapeutically active material. The system comprises a patient interface to introduce the material into the patient's lungs. The patient interface is connected to a flexible inhalation tube and a flexible exhalation tube. The exhalation tube is connected to a filter having an outlet connected to atmosphere. The inhalation tube is connected to an apparatus for providing pulsed amounts of the material entrained in filtered atmospheric air. A control unit operates the pulmonary dosing system in accordance with operator inputs regarding the number of patent exhales between pulses, and pulse length. The exhaust filter and the apparatus for providing pulsed amounts of the therapeutically active material may be enclosed in a containment case and the patient's interface may comprise a mouth tube-mask combination when the therapeutically active material comprises at least one toxic drug.

Pulmonary dosing system and method

A composition used in combination with an electrohydrodynamic device capable of delivering an active ingredient to the aerodigestive system of the user. The composition comprises three or optionally four basic components: an active ingredient; a carrier material in which the active ingredient may be dissolved, suspended, or emulsified; an aerosol properties adjusting material which provides the composition with the physical characteristics required to create an aerosol cloud by electrostatic or electrohydrodynamic means; and optionally at least one excipient that further adjusts, preserves, stabilizes, or enhances the overall performance of the composition.

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Columbus, OH, United States of America

Michael E Placke