University of California

California Institute of Technology

Siemens Medical Solutions Usa, Inc.

Fluidigm Corporation

Michael E Phelps

Nagichettiar Satyamurthy

Jorge R Barrio

Mohammad Namavari

Stephen R Quake

James R Heath

Hartmuth C Kolb

Arkadij M Elizarov

Hsian-Rong Tseng

Antoine Daridon

Jiang Huang

Paul Wyatt

Chung-cheng Lee

Guodong Sui

Tatsushi Toyokuni

Harvey R Herschman

New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

Microfluidic chemical reaction circuits

This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.

Cyclooxygenase-2 selective agents useful as imaging probes and related methods

An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F,in He or other inert gas.

8-fluoropurine compounds

An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F.sub.2 in He or other inert gas.

Process for producing 8-fluoropurines

Growing community of inventors

Los Angeles, CA, United States of America

Michael E Phelps