Mcdata Corporation

The Rockefeller University

Cornell University

Other

Michael E O'Donnell

W Jeffrey Mitchem

Olga Yurieva

Kenneth J Fredericks

John Kuriyan

David Jeruzalmi

Harry M Yudenfriend

Roger Gregory Hathorn

Giles R Frazier

Joseph C Elliott

Jeffrey J Nelson

Richard E Whipple

Robert J Gallagher

Frank Dean

Peter M Holmes

Irina Bruck

Dan Zhang

Richard Whipple

A method includes determining a priority of each of a plurality of frames, wherein the priority is a function of an initial value dependent on content of each said frame and one or more adjustment values independent of content of each said frame, and selecting the frame with the highest determined priority for transmission through the device prior to transmission of any other of the frames. A system includes a receiving port configured to receive frames and assign an initial priority to each frame, a queue configured to insert queue entries associated with received frames on the queue, each queue entry being inserted at a queue position based on the initial priority assigned to the queue entry, the queue further configured to reorder queue entries based on readjusted priorities of the queue entries; and a transmitter switch configured to transmit the frame having the highest priority before transmitting any other frame.

Method for scoring queued frames for selective transmission through a switch

A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified inand corresponds to Polymerase III in. The genes and the polypeptides corresponding to T.th. &#x3b3;, &#x3c4;, &#x3b5;, &#x3b1; and &#x3b2; subunits that they encode are disclosed, as are probes, vectors, methods of preparation and the methods of use. The enzymes of the present invention and their components are particularly well suited for use in procedures for the preparation of DNA, such as PCR, because of the speed and accuracy that they are able to achieve.

Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof

A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in, and corresponds to Polymerase III in. The genes and the polypeptides corresponding to. &#x3b3;, &#x3c4;, &#x3b5;, &#x3b1; and &#x3b2; subunits that they encode are disclosed, as are probes, vectors, methods of preparation and the methods of use. The enzymes of the present invention and their components are particularly well suited for use in procedures for the preparation of DNA, such as PCR, because of the speed and accuracy that they are able to achieve.

The duplex DNA of chromosomes is replicated in a multicomponent process. A helicase unwinds the DNA, a replicase synthesizes new DNA, and primase repeatedly synthesizes new primed starts on the lagging strand. The present invention is directed to the genes from Gram positive bacterium encoding these proteins, and their characterization.

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The present invention relates to beta protein-encoding genes from Gram positive bacterium. Expression systems and host cells containing these genes are also disclosed.

DNA molecules encoding beta clamp proteins of gram positive bacteria

A method for selective transmission of through a switch according to a quality of service level includes providing one or more switches in a fibre channel fabric, particularly one or more fibre channel switches. The method includes assigning an initial score to the content of the one or more frames of data. The initial score may be adjusted by one or more alternative score components to determine one or more adjusted scores. The adjusted scores are compared. The method also provides for selecting frames having the highest adjusted scores and transmitting through the switches the frames having the highest adjusted scores.

The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.

Enzymes derived from thermophilic organisms that function as a chromosomal replicase, preparation and use thereof

The present invention is directed toward the 5 previously unknown genes, for subunits &#x3b4;, &#x3b4;', &#x3c7;, &#x3b8;, and &#x3c8;, of the DNA polymerase III holoenzyme, and toward a unique man-made enzyme containing 5, preferably 6, protein subunits which shows the same activity as the naturally occurring 10 protein subunit DNA polymerase III holoenzyme.

DNA polymerase III holoenzyme

A method for scoring queued frames for selective transmission through a switch ( ) includes providing one or more switches in a fibre channel fabric, particularly one or more fibre channel switches ( &prime;). The method includes assigning an initial score ( ) to the content ( ) of the one or more frames ( ) of data ( ). The initial score ( ) is adjusted by one or more alternative score components to determine one or more adjusted scores ( ). The adjusted scores ( ) are compared. The method also provides for selecting frames ( ) having the highest adjusted scores ( ), and transmitting through the switches ( ) the frames ( ) having the highest adjusted scores ( ).

The present invention is directed to a method for amplifying or sequencing a nucleic acid molecule with a three component polymerase comprising a DNA polymerase component, a sliding clamp component, and a clamp loader component.

Methods for amplifying and sequencing nucleic acid molecules using a three component polymerase

The present invention relates to isolated DNA molecules encoding mammalian single strand gap response proteins involved in activation of a DNA repair/cell cycle checkpoint pathway. Expression systems and host cells containing those DNA molecules as well as the proteins themselves and antibodies raised against them are also disclosed. The DNA molecules, proteins, and antibodies can be used for diagnostic purposes, while the DNA molecules also have therapeutic utility. In addition, transgenic animals can be produced where the gene encoding a single strand gap response protein is disrupted or deleted. As a result, these animals are characterized by spontaneous tumor development.

DNA molecules encoding single strand gap response proteins involved in activation of a DNA repair/cell cycle checkpoint pathway

An in-band method/apparatus whereby a host is enabled to secure predetermined operational information relative to predetermined ports of a fiber channel switch. A set command is generated at the host and sent in-band to the switch. The information content of the set command defines the ports for which operational-parameters are to be monitored. The information content of the set command also defines which operational parameters are to be monitored. In response to receiving the set command, the switch establishes statistical counters for monitoring port operational parameters in accordance with received operational parameter identifiers. An accept signal is then sent in-band to the host, and a time period of port monitoring begins. After a predefined time period has expired, the host sends a read command in-band to the switch. The switch now generates a monitor record in accordance with the count content of the statistical counters that were established in response to the set command. This monitor record contains one port field for each of the ports that were specified by the set command, and each of the port fields contains one or more count fields that contain port operational count data for the port operational parameters that were specified by the set command. The monitor record is then sent in-band to the host. Recycling of the timed process may be provided.

In-band method and apparatus for reporting operational statistics relative to the ports of a fibre channel switch

A method for implementing a link level service in a computer network having a first port device and a second port device. Node identification data is stored in the second port device. A physical-layer communications coupling is provided between the first port device and the second port device which may be a point-to-point, loop, or switched circuit connection. The first port device sends a request node identification (RNID) message addressed to the second port device. The second port device creates an accept message and copies stored node identification data into the accept message. The second port device sends the accept message to the first port device.

Self-description extended link service for networks

A switch including a plurality of input/output (I/O) ports and a switching element programmably coupling a first of the I/O ports with a second of the I/O ports. An analysis device is associated with the first I/O port measuring at least one data traffic parameter specific to data traffic between the first I/O port and the second I/O port.

Growing community of inventors

Hastings-on-Hudson, NY, United States of America

Michael E O'Donnell