Medtronic Minimed, Inc.

Suros Surgical Systems, Inc.

Promex Technologies, LLC

Promex, Inc.

Hologic, Inc.

Emx Corporation

Other

Sdgi Holdings, Inc.

Nico Corporation

Danek Medical

Sdgi Holidings, Inc.

Michael E Miller

Joseph L Mark

Rajiv Shah

Zachary R Nicoson

Raghavendhar Gautham

Jenn-Hann Larry Wang

Terry D Hardin

Rebecca K Gottlieb

Ronald J Lebel

Timothy J Starkweather

Andrea Varsavsky

Dan C Ireland

Jay A Stein

Andrew P Smith

Loren Thomas Niklason

Bahar Reghabi

Michael C Hoffa

John Phillip Hancock

Jacob A Flagle

Kenneth F Defreitas

John LaViola

Bradley J Enegren

Keith Nogueira

Peter Ajemba

Yanan Zhang

Jeffrey Nishida

Andy Y Tsai

John Joseph Mastrototaro

William P Van Antwerp

Mary M Morris

Ning Yang

Robert C Mucic

Wayne A Morgan

Mohsen Askarinya

Akhil Srinivasan

Nannette M Van Antwerp

Ashwin K Rao

Ian Shaw

Kenneth F DeFreitas

Bradley Chi Liang

Ellis Garai

Sarnath Chattaraj

Poonam S Gulati

Anthony J Bradshaw

Brian T Kannard

Yiwen Li

Charles Butcher

Bryan T Burney

Tao Wu

Steven C Jacks

David L Schroeder

William O Hodge

Jake Flagle

Melissa Tsang

Fei Yu

Chi-En Lin

Brian Zimmer

Catherine M Szyman

Justin Smith

Eunjoo Jin

Ronald L Hofmann

Victor Giron

Paris Chen

Daniel John Henry

Miklos T Kara

Brian McCary

Jason M Butcher

Inderjeet S Jarial

Genival D De Barros

Carlos A Callirgos

Manjunath Sirigiri

Joseph Paul Brinson

Guangping Zhang

David Probst

John Laviola

Daniel E Pesantez

Alan M Schechter

Brad Hayden Quinn

Xin Heng

Quyen Ong

Rui Kong

Larry D Maurer

Inthirai Somasuntharam

Michael N Missaghi

Daniel C Ireland

Timothy A Goedde

Parisa Kamgar

Dan D Ireland

Ian M Shaw

Ariel Reider

Carlos E Maldonado

Andrea Varsavsly

Kenneth De Freitas

The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

Sensors for 3-hydroxybutyrate detection

A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods

A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

Methods, systems, and devices for calibration and optimization of glucose sensors and sensor output

Methods, devices, apparatuses and systems are disclosed for performing mammography, such as utilizing tomosynthesis in combination with breast biopsy.

Breast biopsy and needle localization using tomosynthesis systems

Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

In-vivo electrochemical impedance spectroscopy (EIS)-based calibration

Embodiments of the invention provide multilayer analyte sensors having elements and/or architectures that function to improve oxygen delivery to sensor enzymes in manner that enhances sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Methods to improve oxygen delivery to implantable sensors

The invention includes method and materials designed to measure the material properties (e.g. thickness) of layers of material in a sensor using non-Faradaic EIS (Electrochemical Impedance Spectroscopy) methods. The methods are non-destructive, very sensitive and rapid. Typically in these methods, an AC voltage is applied to the desired material layer while the output current and therefore impedance is measured. This voltage can be applied in multiple frequencies in sweep mode in order to detect both the material and, for example, the thickness of the target material. In this way, EIS allows the characterization of properties of various layers of material disposed in devices such as electrochemical glucose sensors.

Measurement of device materials using non-Faradaic electrochemical impedance spectroscopy

Use of electrochemical impedance spectroscopy (EIS) in intelligent diagnostics

A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

System and method for providing closed loop infusion formulation delivery

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Trafalgar, IN, United States of America

Michael E Miller