Cephalon, Inc.

Kyowa Hakko Kogyo Co., Ltd.

Other

Albert Einstein College of Medicine

Cara Therapeutics, Inc.

Kyowa Hakko Kogyo

Michael E Lewis

James C Kauer

Nicola T Neff

Kathleen V Callison

Jill M Roberts-Lewis

Chikara Murakata

Hiromitsu Saito

Yuzuru Matsuda

Marcie A Glicksman

Kevin R Smith

Mohamed A Iqbal

Fumihiko Kanai

John A Kessler

Stuart C Apfel

Masami Kaneko

Frank Baldino, Jr

Frank Baldino

Derek T Chalmers

Richard C Lewis

Donna Bozyczko-Coyne

Rodney E Schapel

Methods for elevating and stabilizing prolactin levels in a mammal including methods of treating disorders and conditions associated with reduced serum levels of prolactin are provided. Also provided are methods of using certain synthetic tetrapeptide amides which are peripherally selective kappa opioid receptor agonists to elevate or stabilize serum prolactin levels.

Method for elevating prolactin in mammals

A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method comprising administering to the mammal an effective amount of one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.

Treating disorders by application of insulin-like growth factors and analogs

Disclosed is a method for promoting retinal neuronal survival in a mammal, wherein the neuronal cells are at risk of dying. The method comprises administering to the mammal an effective dose of at least one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; or a functional derivative of IGF-II.

Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs

An apparatus for prevention of corrosion in metal objects uses a pad having a conductive facing, a dielectric substrate and an adhesive, attached to a metal body being protected from corrosion. The metal body and the negative terminal of a source of DC voltage (battery) are grounded. The positive terminal of the source of DC voltage is connected to electronic circuitry that imparts pulses of low voltage DC to the conductive facing of the pad. These pulses of electrical current inhibit the oxidation of the metal object by providing a source of electrons to the oxidizing chemicals in contact with the metal. The electronic circuitry includes a reverse voltage protector to prevent the application of reverse source voltage. The circuitry also includes a power conditioner to supply a constant DC voltage to a microprocessor. The microprocessor generates pulses of DC signals that are amplified by a pulse amplifier and imparted to the conductive facing of the pad. The invention also includes a battery voltage monitor and a power indicator. When the battery voltage drops below a reference level, the microprocessor senses this low voltage condition and shuts off operation of the pulse amplifier, thereby conserving battery power.

Process and apparatus for preventing oxidation of metal

Treating disorders by application of insulin-like growth factors and

The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.

Protein kinase inhibitors for treatment of neurological disorders

Protein kinase inhibitors for treatmen of neurological disorders

A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method comprising administering to the mammal an effective amount of at least one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.

A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method including the step of administering to the mammal one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; a functional derivative of IGF-II; IGF-III; or a functional derivative of IGF-III.

The invention features a method of using insulin-like growth factor-I (IGF-I) or insulin-like growth factor-III (IGF-III) to prevent or treat peripheral neuropathy in a mammal.

Prevention and treatment of peripheral neuropathy

K-252a derivatives for treatment of neurological disorders

Growing community of inventors

West Chester, PA, United States of America

Michael E Lewis