Merrell Dow Pharmaceuticals

Eli Lilly and Company

Michael E Le Tourneau

Norton P Peet

Michael J Martinelli

Michael Gregory Bell

Mark Alan Winter

The present invention provides compounds of formula (I): wherein W represents hydrogen, C -C alkyl, &mdash;CH CO H, or CO H; and X represents hydrogen, C -C alkyl, &mdash;CH CO H, or CO H; with the proviso that at least one of W or X must be other than hydrogen; or a prodrug or a pharmaceutically acceptable salt thereof; which are useful for treating migraine.

Selective iglur5 receptor antagonists

The present invention is directed to a group of methylated tetrahydro cyclohepta[1,2-c:4,3-c']dipyrazoles and benzo[1,2-c:4,3-c']dipyrazoles useful as bronchodilators. The compounds are prepared by the reaction of an appropriate hydrazine with an appropriate 1,3-diketone or with a compound that is chemically equivalent to a 1,3-diketone.

Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators

A group of variously methyl-substituted[1,2-c:3,4-c']dipyrazoles, cyclohepta[1,2-c:3,4-c']dipyrazoles, and cyclopenta[1,2-c:3,4-c']dipyrazoles useful as bronchodilators are described herein. The compounds are prepared by reacting a 1,3-diketone with hydrazine or methylhydrazine to give tricyclic products optionally followed by catalytic dehydrogenation and/or alkylation with a strong base and methyl iodide to give various other compounds within the scope of the invention.

Dipyrazoles and their use as bronchodilators

The present invention is directed to a group of compounds which are variously methylated thiopyranodipyrazoles and to the S-oxides and S-dioxides of such compounds. The compounds are useful as bronchodilators and are prepared by the reaction of appropriately 5-substituted thiopyrano[3,4-c]pyrazol-4-(1H)-one with a hydrazine.

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Indianapolis, IN, United States of America

Michael E Le Tourneau