University of California

Alnylam Pharmaceuticals, Inc.

Arbutus Biopharma Corporation

American Cyanamid Company

Merck Sharp + Dohme Corp.

Lawrence Livermore National Security, LLC

Isis Pharmaceuticals, Inc.

Other

University of Illinois

The United States Government As Represented by the Department of Veterans Affairs

Cubist Pharmaceuticals, Incorporated

University of Louisville Research Foundation, Inc.

Mcgill University

Cylene Pharmaceuticals, Inc.

Tekmira Pharmaceuticals Corporation

Michael E Jung

Muthiah Manoharan

Charles L Sawyers

John Wongvipat

Chris Tran

Samedy Ouk

Kallanthottathil G Rajeev

Richard J Pietras

Dongwon Yoo

Muthusamy Jayaraman

David Butler

Farhad Parhami

Gang Deng

John M Finn

Xiaoming Li

Junhu Zhang

Xiaoguang Liu

Zhiyong Chen

Thanh To Lam

Michael Trzoss

William E Lowry

Robert Damoiseaux

Heather R Christofk

Aimee Flores

Diana C Marquez-Garban

Yanpeng Xing

John F Finn

Leslie William Tari

Sergio E Wong

Felice C Lightstone

Daniel Bensen

Suk Joong Lee

Kallanthottahil G Rajeev

David A Nathanson

Charlie D Chen

Toan B Nguyen

Khanhlinh Nguyen

Paul Krogstad

Jun Zuo

Phillip Dan Cook

Jue Wang

Jayaprakash K Nair

Andrei P Guzaev

Andrew Mamoru Kawasaki

Nagichettiar Satyamurthy

Philip Mark Harrington

Rhonda R Voskuhl

Michael Morytko

George Just

Douglas W Phillipson

Jennifer Marie Murphy

Caius G Radu

Arnon Lavie

Richard A Gatti

Rajendra K Pandey

Frank Stappenbeck

Jianchao Wang

Yanzhi Zhang

Derek S Welsbie

Raymond M Gipson

Gang Wang

Zheng Li

Matthew Rettig

D Elshan Nakath G Ralalage

Peter M Clark

Jiabin An

Liutao Du

Jin-Mo Ku

Min Teng

Jeffrey Paul Whitten

Barrington Cross

Marinus Los

Robert F Doehner, Jr

Owen N Witte

Jerry L Johnson

Peter J Wepplo

David W Ladner

Fabrice Pierre

Michael Schwaebe

Allen Borchardt

George Yiannikouros

Victor M Kamhi

Robert H Schiestl

Jing Huang

Christopher John Creighton

Narayanannair K Jayaprakash

Mark Hilgers

William M Pierce, Jr

Shin-Shyong Tseng

Charlie Chen

Collin Regan

Benhur Lee

Allister S Fraser

Dimitrios Iliopoulos

Xudong Fu

Karen Lynn Reue

K Grant Taylor

Brett Eugene Lomenick

Mark Stidham

Laurent Vergnes

The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.

Inhibitors of the Wnt/beta-catenin pathway

The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

Compositions and methods for modulating hair growth

The present disclosure provides compounds of Formula (VIIb) and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

Inhibitors of the n-terminal domain of the androgen receptor

Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I).

Lipid compositions

The present disclosure provides compounds and compositions capable of treating cancer or an autoimmune disease, such as Crohn's disease, and methods of use thereof.

Compositions and methods for treating epigenetic disease

The present technology provides compounds according to Formulas (I), (II), or (III) useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus.

Potent antiviral pyrazolopyridine compounds

Provided herein are hydantoin compounds useful for the prevention or treatment of hyperproliferative diseases or disorders. Exemplary hydantoin compounds include substituted diazaspiroalkanes, such as (A51) and (A52) having the following structures:

Substituted diazaspiroalkanes as androgen receptor modulators

Inhibitors of the WNT/beta-catenin pathway

Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-&#x3b2; ligand (ER&#x3b2; ligand).

Estrogen receptor ligands, compositions and methods related thereto

The present disclosure provides compounds of Formula (VIA), Formula (IIIA), Formula (IVA), and Formula (VA). The compounds are prodrugs of alpha-ketoglutarate, alpha-ketobutryrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, which are useful in treating or preventing age related diseases, disorders, or conditions. 

Prodrugs of alpha-ketoglutarate, alpha-ketobutyrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, and uses thereof

The present disclosure relates to compounds, compositions and methods for treating cancer, including compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating cancer in the brain, including glioblastoma and other EGFR mediated cancers. The disclosure further relates to methods of treating cancers such as glioblastoma and other EGFR mediated cancers that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.

Compositions and methods for treating cancer

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

Inhibitors of the N-terminal domain of the androgen receptor

Growing community of inventors

Los Angeles, CA, United States of America

Michael E Jung