Genevant Sciences Gmbh

Michael E Houston

Mary Gallagher Prieve

Sean D Monahan

Anna Galperin

Debashish Roy

Michael S Declue

Pierrot Harvie

Mary G Prieve

Charbel Diab

Maher Qabar

Michael S DeClue

Amber E Paschal

Russell N Johnson

Jean-Rene E Ella-Menye

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Block copolymers

Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

Branched peg molecules and related compositions and methods

Growing community of inventors

Kirkland, WA, United States of America

Michael E Houston