University of Louisville Research Foundation

Other

Michael E Brier

Adam E Gaweda

Jon B Klein

Michael L Merchant

George R Aronoff

Alfred A Jacobs

A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile.

System and method for personalized dosing of pharmacologic agents

Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent.

Methods and kits for predicting a response to an erythropoietic agent

Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17.

A process for producing hydrophobic cotton fabric useful as material for forming a wide variety of useful articles. The process includes the steps of (1) bleaching the cotton fabric with a suitable optical whitener; (2) affixing the fabric to a conveying machine; (3) applying approximately 7 lbs. of water resistance substance for each approximately 100 lbs. of fabric by conveying the fabric through a pad bath; (4) conveying the fabric through a tenter frame machine having a heating chamber set a approximately 340&deg; F.; (4) conveying the treated fabric through the heating chamber at a speed of approximately 17 yards per minute; (5) repeating step 4 a second time to effect curing of the chemicals thereby resulting in a water-resistant cotton fabric. Alternate methods are disclosed for treating fabric with various antimicrobial, antifungal, anti-odor and/or anti-stain substances. Fabric produced according to the above-referenced process is suitable for use in a wide variety of useful articles such as undergarments for those suffering from incontinence, feminine shields, bedding products such as mattress pads and covers, apparel such as t-shirts, lingerie, and medical gowns.

Growing community of inventors

New Albany, IN, United States of America

Michael E Brier