Biomay Produktions- Und Handelsgesellschaft M.b.h.

Biomay Biotechnik Produktions Und Handelsgesellschaft M.b.h.

Michael Duchene

Rudolf Valenta

Dietrich Kraft

Michael Breitenbach

Otto Scheiner

Helmut Rumpold

Karin Pettenburger

The invention provides recombinant DNA molecules which code for polypeptides that exhibit the antigenicity of a P14 allergen of birch Betula verrucosa and other plants of the order Fagales, and for polypeptides comprising at least one epitope thereof, as well as nucleic acids which under stringent conditions hybridize with such DNA sequences or are derivable from such sequences by degeneracy of the genetic code. A method is provided that permits purification of P14 allergens or cross reactive allergens by means of binding to poly(L-proline). In addition, methods are described for making the proteins and polypeptides coded by these DNA molecules and their use in the diagnosis or therapy of diseases.

Method of production of birch pollen allergen P14

Birch pollen allergen P14 for diagnosis and therapy of allergic diseases

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Vienna, Austria

Michael Duchene