University of British Columbia

University System of Maryland

Michael Donnenberg

B Brett Finlay

Brendan Kenny

Markus Stein

Li-Ching Lai

The present invention relates to engineeredtype IV pilin (tfp) genes, type IV pilin proteins which can serve as a diagnostic marker for identification of patients infected with, and vaccines comprising type IV pilin proteins, antigenic fragments and variants thereof for therapeutic interventions.

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The present invention provides a polypeptide, called EspA, which is secreted by pathogenic, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC). The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing

The present invention provides a polypeptide, called EspA, which is secreted by pathogenic, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC). The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing

The present invention provides the EspA polypeptide, which is secreted by pathogenic such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) Diagnosis of disease caused by such pathogenic can be performed by standard techniques, such as those based upon the use of antibodies which bind to EspA to detect the protein, as well as those based on the use of nucleic acid probes for detection of nucleic acids encoding EspA protein. The invention also provides isolated nucleic acid sequences encoding EspA, EspA polypeptide, EspA peptides, a method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing The invention also provides a method of immunizing a host with EspA to induce a protective immune response to EspA.

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Baltimore, MD, United States of America

Michael Donnenberg