Bayer Aktiengesellschaft

Bayer Cropscience Ag

Saltigo Gmbh

Lanxess Deutschland Gmbh

Bayer Intellectual Property Gmbh

Michael Dockner

Norbert Lui

Alexander Klausener

Wahed Ahmed Moradi

Thomas Himmler

Reinhard Langer

Walter Lange

Markus Eckert

Joachim Komoschinski

Peter Bruechner

Thomas-Norbert Müller

Torsten Neugebauer

Stephan Ratsch

Reiner Fischer

Heiko Rieck

Horst Behre

Werner Lindner

Albert Schnatterer

Lars Rodefeld

Jens-Dietmar Heinrich

Julia Johanna Hahn

Wolfgang Eymann

Ulrich Scholz

Thomas Wollner

Bernd-Michael K&ouml;nig

Peter Brüchner

Jens Dietmar Heinrich

Jürgen Wieschmeyer

Helmut Holzem

Thomas Jagusch

Jürgen Wieschemeyer

The present invention relates to a novel process for preparing substituted cyclohexane amino acid esters and spiroketal-substituted cyclic keto-enols, and to novel intermediates or starting compounds that are passed through or used in the process according to the invention.

Process for preparing substituted cyclohexane amino acid esters and spiroketal-substituted cyclic keto-enols

The present invention relates to a novel process for the esterification of N-acylated amino acids which contain an acid-labile keto protective group under alkaline conditions without using a polar aprotic solvent, in which the N-acylated amino acid with acid-labile keto protective group prepared in situ is esterified using an alkyl halide or a mono- or dialkyl ester of sulfuric acid.

Process for preparing esters of N-acylated amino acids with acid-labile keto protective group functions

The present invention relates to a process for preparing substituted biphenylanilides of the formula (I). 

Process for preparing chlorinated biphenylanilides and biphenylanilines

The present invention relates to a process for preparing substituted biphenylanilides of the formula I   

Process for preparing substituted biphenylanilides

The present invention relates to a process for the preparation of substituted biphenyls by reacting aryl halides with tetraarylborates in the presence of palladium catalysts.

Tetraarylborate process for the preparation of substituted biphenyls

The present invention relates to a process for preparing 2-fluoroacyl-3-aminoacrylic acid derivatives by reacting fluorinated carboxylic acids with dialkylaminoacrylic acid derivatives and acid halides.

Method for the production of 2-fluoroacyl-3-aminoacrylic acid derivatives

What is described is a process for preparing 2-hydroxyacetals of the general formula in which Ris hydrogen, a branched or unbranched C-C-alkyl radical, an electron-deficient, halogen-, NO&#x2014;, CN&#x2014;, CF&#x2014;, acyl group- or branched or unbranched alkyl group-substituted or unsubstituted C-C-aryl or heteroaryl, and Ris a branched or unbranched C-C-alkyl radical, or both Rradicals are bonded directly to one another or to one another via a C-Cunit, by reacting an enol compound of the general formula (II) in which Ris the same and Ris as defined for formula (Ia), with bromine to give the corresponding dibromo adduct and then reacting this dibromo adduct with an alkoxide of the general formula (III) M-O&#x2014;R(III) in which Ris as defined for formula (Ia) and O is oxygen and M is lithium, sodium or potassium. What is likewise described is the preparation of the corresponding 2-hydroxyalkanals from the 2-hydroxyacetals thus obtained by acidic hydrolysis.

Process for preparing 2-hydroxyacetals and the corresponding 2-hydroxyalkanals

The invention relates to a novel process for preparing 2-phenoxyacetals and the corresponding 2-phenoxycarbaldehydes. These compounds are important intermediates for the preparation of active pharmaceutical ingredients.

Method of producing 2-phenoxyacetals and the corresponding 2-phenoxy-carbaldehydes therefrom

Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about &#x2212;5 to about +100&#xb0; C. Some of the cinnamic acids and cinnamic acid derivatives obtainable in this way are new. Cinnamic acids and cinnamic acid derivatives which can be prepared according to the invention can be used for the preparation of indanones which are precursors for agro- and pharmaceutical chemicals and for substances having liquid-crystalline properties.

Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives

A process is provided for preparing optionally substituted arylated benzylamines from the corresponding optionally substituted aryl halides and optionally substituted benzylamines using a specific solvent mixture, a base and a catalyst comprising a palladium compound and a bisaryldialkylphosphine.

Process for coupling benzylamines with haloaromatics

An advantageous process is provided for preparing methyl 4-(aminomethyl)benzoate by esterifying 4-(aminomethyl)benzoic acid and subsequently obtaining the methyl 4-(aminomethyl)benzoate, this process proceeding under specific pH and temperature control and isolation of the hydrochloride of methyl 4-(aminomethyl)benzoate formed as an intermediate being avoidable.

Process for preparing methyl 4-(aminomethyl)benzoate

2-Alkyl-3-aryl- or -heteroaryloxaziridines are prepared in a particularly advantageous manner by oxidizing corresponding N-alkyl-aryl- or -heteroarylaldimines with an aromatic percarboxylic acid or a salt thereof in the presence of water, a water-soluble base, and a water-miscible solvent, at temperatures below 30&#xb0; C. Using this method, it is also possible to obtain novel 2-alkyl-3-aryloxaziridines.

Process for preparing 2-alkyl-3-aryl- and -heteroaryloxaziridines and novel 2-alkyl-3-aryloxaziridines

2-Alkyl-3-aryl- or -heteroaryloxaziridines are prepared in a particularly advantageous manner by oxidizing corresponding N-alkyl-aryl- or -heteroarylaldimines with an aromatic percarboxylic acid or a salt thereof in the presence of water, a water-soluble base, and a water-miscible solvent, at temperatures below 30&deg; C. Using this method, it is also possible to obtain novel 2-alkyl-3-aryloxaziridines.

Process for preparing 2-alkyl-3aryl-and-heteroaryloxaziridines and novel 2-alkyl-3-aryloxaziridines

A process is provided for preparing 4-hydroxy-3-nitrobiphenyl from 4-hydroxy-biphenyl by nitrating in the position adjacent to the phenolic hydroxyl group in high selectivity and yield, and the nitric acid used as the nitrating reagent is metered into the reaction system in a specific manner.

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Kö'ln, Germany

Michael Dockner