Imperial Chemical Industries Limited

Other

Michael Derek Edge

Enno Christophers

Wilson S Waring

Jens-Michael Schroder

Oliver Wiedow

David Pioli

Polypeptides, in particular the polypeptide of formula I: and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such asand yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.

Nucleic acids

Processes for the preparation of biotinylated polynucleotides and analogues thereof and protected intermediate products for use in such processes are described and claimed. The processes may be conveniently used in the automated synthesis of biotinylated polynucleotide on a DNA synthesizer. The polynucleotides so prepared may be used as labelled probes e.g. as diagnostic tools for clinical and research uses.

Protected biotin derivatives

The invention concerns novel 2-[4-(4-chlorophenyl)benzyloxy]acetic acids of the formula: ##STR1## in which R.sup.1 is hydrogen or (1-4C)alkyl, R.sup.2 is phenyl optionally bearing a halogeno substituent, and R.sup.3 is hydrogen or (1-4C)alkyl, and when R.sup.3 is hydrogen pharmaceutically acceptable base-addition salts thereof; and processes for their manufacture. The compounds possess useful anti-arthritic properties coupled with desirable pharmacokinetic properties and the minimum of adverse properties, and the invention also concerns pharmaceutical compositions of such compounds for use in the treatment of arthritic joint diseases. A typical compound of the invention is 2-[4-(4-chlorophenyl)benzyloxy]-2-phenyl propionic acid.

Hydroxyacetic acid derivatives with anti-arthritic properties

The invention concerns novel hydroxyalkanoic acid derivatives of the formula: ##STR1## in which A is a straight or branched chain (2-6C)alkylene, R.sup.1 and R.sup.2 are independently hydrogen or (1-6C) alkyl, and R.sup.3 is hydrogen or (1-6C)alkyl, and when R.sup.3 is hydrogen, base-addition salts thereof; and processes for their manufacture. The compounds possess useful anti-arthritic properties and the invention also concerns pharmaceutical compositions of such compounds for use in the treatment of arthritic joint diseases. A representative compound of the invention is 2-{2-[4-(4-chlorophenyl)phenyl]-ethoxy}propionic acid.

Growing community of inventors

Congleton, United Kingdom

Michael Derek Edge