Aventis Cropscience S.a.

Bayer Cropscience Ag

Rhone-poulenc, Inc.

Michael David Tomalski

Xiao-Zhuo Michelle Wang

Vincent Paul Mary Wingate

Xavier Georges Sarda

Daniel B Gant

The present invention is directed to a nucleic acid encoding a lepidopteran glutamate-gated chloride channel. Vectors and host cells comprising the nucleic acid are also provided. A method of identifying agents that modulate the activity of a lepidopteran glutamate-gated chloride channel is also provided. Such agents are useful as insecticides.

Heliothis glutamate receptor

Method of identifying an agent that modulates the activity of a lepidopteran glutamate-gated chloride channel

Nucleic acid encoding lepidoteran glutamate-gated chloride channel

The present invention provides a method of measuring the ability of a compound to bind to the GABA recognition site of an insect GABA receptor. The invention further provides host cells that express a nucleic acid encoding the GABA receptor subunit LCCH3 and a nucleic acid encoding the GABA receptor subunit Grd, and cell membranes obtained from the host cells.

Method of identifying compounds that bind to the insect gaba receptor

Growing community of inventors

Raleigh, NC, United States of America

Michael David Tomalski