Nektar Therapeutics

Serina Therapeutics, Inc.

Nektar Therapeutics Al, Corporation

Shearwater Corporation

Applied Research Systems Ars Holding N.v.

Serina Therapeutics (al), Inc.

Other

United Therapeutics Corporation

Shearwater Polymers, Inc.

Sarina Therapeutics, Inc.

Michael David Bentley

Xuan Zhao

J Milton Harris

Zhihao Fang

Tacey Viegas

Xiaoming Shen

Kunsang Yoon

Antoni Kozlowski

Samuel P McManus

Rebecca Weimer

Mary J Bossard

Randall Moreadith

Lin Cheng

Ping Zhang

Sean M Culbertson

Zhongxu Ren

Stephen A Charles

Lihong Guo

William Dudley Battle, Iii

Bekir Dizman

Michael James Roberts

Jennifer A Riggs-Sauthier

Tony L Sander

Richard R Goodin

Francesco Maria Veronese

Nabil El-Tayar

Randall W Moreadith

Wen Zhang

Michael Reif

Samuel P Mcmanus

Robert G Shorr

Guerin D Rife

Martine A Rothblatt

David B Leadbetter

Harold Zappe

Jeremy Lloyd Clark

Xuan Zhoa

Anna Mero

Robert J Sharpe

Rainer Jordan

Rainer Jordon

Kevin Burton

William Dudley Battle

Ribecca Weimer

Xioaming Shen

Xuan N 217 Building 2 Xiao Huang Zhao

Tracey X Viegas

Milton J Harris

Samuel Mcmanus

Kusang Yoon

The present disclosure provides for polyoxazoline (POZ) conjugates wherein the conformation of the POZ conjugate and the release rate of an agent from the POZ conjugate can be controlled by selecting one or more characteristics of the POZ polymer. Methods of controlling the conformation of a POZ conjugate and the release rate of an agent prior are provided as well as methods of treatment using such POZ conjugates and methods. Pharmaceutical compositions comprising a POZ conjugate are also provided.

Polyoxazoline-drug conjugates with novel pharmacokinetic properties

Polyoxazoline (POZ) conjugates wherein the conformation of the POZ conjugate and the release rate of an agent from the POZ conjugate can be controlled by selecting one or more characteristics of the POZ polymer and methods of controlling the conformation of a POZ conjugate and the release rate of an agent prior are provided as well as methods of treatment using such POZ conjugates and methods. Pharmaceutical compositions including a POZ conjugate are also provided.

POZ-lipid conjugates and lipid nanoparticles (LNPs) including POZ-lipid conjugates used to facilitate delivery of an encapsulated payload. LNPs including POZ-lipid conjugates and a nucleic acid payload such as, but not limited to, mRNA or modified mRNA are disclosed. Such LNPs have no immunogenicity or reduced immunogenicity as compared to a corresponding LNP containing a PEG-lipid.

Polyoxazoline-lipid conjugates and lipid nanoparticles and pharmaceutical compositions including same

Methods of preparing monodisperse oligomer reagent compositions such as oligo(ethylene glycol) reagent compositions are described herein. The methods involve reacting a halo-terminated oligomer such as an oligo(ethylene oxide) having (m) monomers with a hydroxyl-terminated oligomer such as a hydroxyl-terminated oligo(ethylene oxide) having (n) monomers.

Methods of preparing a monodisperse oligo(ethylene glycol) reagent composition

The present disclosure provides polymer conjugates comprising a polymer and an agent the agent linked to the polymer via a linking group containing a cleavable moiety.

Subcutaneous delivery of polymer conjugates of therapeutic agents

The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.

Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same

Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.

Cleavable conjugates of catechol compounds and water-soluble polymers and methods of treatment using the same

The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water-soluble oligomer.

Oligomer-corticosteroid conjugates

Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.

Polymer derivatives having particular atom arrangements

The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.

Subcutaneous delivery of polymer conjugates of therapeutics agents

The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates

The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.

Subcutaneous delivery of poly(oxazoline) polymer conjugates

Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.

Method of making a water-soluble polymer-factor VIII moiety conjugate

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Huntsville, AL, United States of America

Michael David Bentley