University of Maine System

The Jackson Laboratory

Michael Darin Mason

David Gregg Holomakoff

Muhammad Radowan Hossen

Joerg Bewersdorf

Sam Hess

The present invention provides, inter alia, biocompatible porous structural materials made exclusively or almost exclusively from nanocellulose fibers (CNF), CNC, or bacterial cellulose, as well as processes for making and using provided compositions. Provided compositions may possess specifically tailored mechanical strength properties and have a design-controlled porosity that is homogeneous or graded, depending on the application. Provided compositions may be manufactured by the controlled dewatering of suspensions of CNF. In some embodiments, provided compositions may include a solids concentration of about 10% to about 95% by weight. Controlled water removal and pore homo- or heterogeneity may be accomplished by controlling capillary, hydrostatic and evaporative processes in the environment of a porous mold around the CNF slurry. A freeze drying or vacuum drying step may be used to complete the drying process, locking in the porous network structure resulting in a predetermined porosity (pore volume/total volume), and pore size distribution.

Controlled porosity structural material with nanocellulose fibers

A method of performing 3D photoactivation microscope imaging includes providing a sample having a plurality of probes, each of the plurality of probes including a photo-activatable material. Probes from the plurality of probes are activated to form a sparse subset of probes, the sparse subset of probes having probes that are spatially separated by at least a microscope resolution. The sample is illuminated with a readout light source, and light emitted from activated probes is detected. Based on the light emission detected from the activated probes, localized three-dimensional positions of the activated probes are obtained.

Growing community of inventors

Orrington, ME, United States of America

Michael Darin Mason