Pfizer Vaccines, Lcc

Ignite Immunotherapy, Inc.

Michael Dale Eisenbraun

Brian Robert Champion

Brian Gregory Pierce

Xiayang Qiu

Julie Jia Li Hawkins

David Michael Wyatt

James Richard Merson

Jakir Hussain Ullah

Leonard Gabriel Contillo, Jr

James Downey Fraser

David H Kirn

Joseph John Binder

Douglas Hanahan

Liliana Maruri Avidal

Clare Lees

Jr Leonard Gabriel Contillo

The present disclosure provides a replication-competent, recombinant oncolytic vaccinia virus; and compositions comprising the replication-competent, recombinant oncolytic vaccinia virus. The present disclosure also provides use of the vaccinia virus or composition for inducing oncolysis in an individual having a tumor.

Recombinant vaccinia virus and methods of use thereof

The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

PCSK9 vaccine

The present invention relates to the provision of immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

Growing community of inventors

San Diego, CA, United States of America

Michael Dale Eisenbraun