Life Technologies Corporation

Los Alamos National Security, LLC

Merck + Co., Inc.

Triad National Security, LLC

Fei Deutschland Gmbh

Other

Thermo Fisher Scientific (bremen) Gmbh

Thermo Fisher (bremen) Gmbh

Dolby Laboratories Licensing Corporation

Dolby International Ab

Danisco US Inc.

Genencor International, Inc.

Dupont Nutrition Biosciences Aps

Clintec Nutrition Company

Danisco US Inc., Genencor Division

Michael D Ward

Gregory Kaduchak

Carleton C Stewart

Nigel S Dunn-Coleman

Frits Goedegebuur

Jian Yao

Alexander Alekseevich Makarov

Jeffrey Charles Riedmiller

Robert C Johnson

Scott Douglas Power

Harald Mundt

Karl Jonas Roeden

John M Williams

Suzanne E Lantz

Louis S Crocker

Kathleen A Clarkson

Michael A Grant

Raymond Cvetovich

Ronald B Jobson

Karel M J Brands

Marguerite A Cervin

Rhonda J Wilson

Daniel Richard Sidler

Cherry Lin

Benjamin S Bower

Huaming Wang

Scott Gregory Norcross

Andrei Miasnikov

Elizabeth Ann Bodie

Glen W Davis

Cody Collier Henderson

Jolene Ann Bradford

Wouter Vervecken

Wesley Glen Smith

Rainer Daum

Birgitta Leuthner

Sang-Kyu Lee

Craig E Pilgrim

Masoud Rajabi Zargahi

Richard Cotter

David C Madsen

Oliver Kensch

Jing Ge

Luis Humberto Garcia-Rubio

Robert Paul

Roger Wallace Dressler

Timothy C Dodge

Mark S Gebert

James Kolozs

Xiaogang Gu

Ulrich Kettling

Jason Malkin

John Dominic Jackson

Amar J Mahajan

Elizabeth S Fisher

Dmitriy Strelkov

Jace Akerlund

Karel M Brands

Mai Faurschou Isaksen

Phillip Nolan Tyler

Michael W Schelle

Saul Selberg

Sean Michael Cole

Zhongqiang Chen

James A Sweigard

Michael Wayne Olszowy

Aleksandra Virag

Steve Sungjin Kim

Peter C Stark

Jimmy Chan

Rikke Høegh Lorentsen

Susan M Madrid

Mingmin Song

Danfeng Song

John M Dunbar

Robert M Wenslow, Jr

José A Olivares

Pieter Van Solingen

Klaus Pellengahr

Charles Orella

Ken Lefton

John W Elling

Roman Rabinovich

Anthony J Valicenti

Rochelle Nguyen

Robert M Wenslow

Douglas Ko

William Lunt Godfrey

Jan Zwierstra

Ian Bradley Thorne

Robin Carlton Swain

David Anton Van Gogh

Chuanbin Liu

Michel Friesenhahn

Eduardo Zurek

Jeffrey V Wheat

Peter Plumstead

The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.

Apparatuses, systems and methods for imaging flow cytometry

Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device includes an optical assembly, a sample stage, and a receiver. The optical assembly enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume toward the receiver. A laser focus detection unit including at least one reference laser and photodetector generates at least one real-time detection signal indicative of one or more characteristics of the sample during ablation and/or of a distance from the objective to the sample stage or a surface of the sample. A controller coupled with the laser focus detection unit dynamically controls in real-time one or more parameters of the ablation laser and/or a position of the objective and/or a position of the receiver relative to the sample to improve MS imaging quality.

Systems and methods for imaging and ablating a sample

The present invention is a method and apparatus for acoustic focusing hardware and implementations.

System and method for acoustic focusing hardware and implementations

Provided are systems and methods that allow for brightfield imaging in a flow cytometer, allowing for collection of fluorescence and high-quality image date. The disclosed technology also gives rise to an illumination pattern that allows a user to create different oblique or structured illumination profiles within a static system. With the disclosed approach, a user can illuminate a sample from a first direction (e.g., with laser illumination configured to give rise to one or more of fluorescence information and scattering information), collect scattering information from a second direction, collect fluorescence information from a third direction, and capture an image of the sample from a fourth direction. (Two or more of the foregoing can be accomplished simultaneously.) Also as described elsewhere herein, an illumination used to illuminate the sample for visual image capture can be communicated to the same through a lens that also collects fluorescence from the sample.

Systems and methods for improved imaging and fluorescence in flow cytometry and other applications

Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device () includes an optical assembly (), a sample stage (), and a receiver (). The optical assembly () is disposed in an inverted position below the sample stage () and the receiver () is positioned above the sample stage (). The optical assembly enables imaging of a sample disposed on the sample stage (). The optical assembly () also enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume () toward the receiver ().

The present invention comprises methods and systems that use acoustic radiation pressure.

Particle analyzing systems and methods using acoustic radiation pressure

The present invention is a method and apparatus for acoustically manipulating one or more particles.

Particle analysis in an acoustic cytometer

The present invention provides systems and methods for using acoustic radiation pressure to fractionate particles within a fluid.

An embodiment of a system with a minute measure of pulsatility in a flow of a fluid is described that comprises a first pump configured to flow the fluid to a junction at a first flow rate that comprises a measure of pulsatility; and a second pump configured to flow a portion of the fluid from the junction at a second flow rate that is less than the first flow rate to produce a flow of the fluid at a third flow rate from the junction with a minute measure of pulsatility.

System and method for providing stable fluid flow

The present disclosure provides devices, systems and methods for concentrating particles after application of a field and flipping the direction of the particles. The field applied to the particles can be an acoustic field. The particles can be flipped from a first flow stream at a higher speed into a second flow stream at a lower speed to aid in concentrating the particles, including concentration within an analysis region.

Methods, systems and devices for concentration of particles

Growing community of inventors

Los Alamos, NM, United States of America

Michael D Ward