Amunix Operating Inc.

Charles River Laboratories International, Inc.

Charles River Laboratories, Inc.

Michael D Scholle

Volker Schellenberger

Willem P Stemmer

Chia-wei Wang

Andreas Crameri

Mikhail Popkov

Nathaniel C Gordon

John C Sherrill

Chia-Wei Wang

John Sherrill

Articles and methods involving detection of binding between two or more species using MALDI are generally provided. In some embodiments, a method comprises exposing a first species to a composition comprising a second species, capturing the first species on a self-assembled monolayer, and performing MALDI on the self-assembled monolayer to generate a signal from the second species and a signal from a standard species present in the self-assembled monolayer. A ratio (first ratio) of the signal from the second species to the signal from the standard species may be compared to a cutoff value in order to determine if binding has occurred. This method may allow determination of a relative affinity of the second species for the first species.

Articles and methods involving detection of binding

The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.

Biologically active proteins having increased in vivo and/or in vitro stability

Unstructured recombinant polymers and compositions comprising same

Unstructured recombinant polymers and uses thereof

The present invention provides methods of using unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities, and the uses thereof. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.

Methods for production of unstructured recombinant polymers and uses thereof

Growing community of inventors

Mountain View, CA, United States of America

Michael D Scholle