Other

Marshall University Research Corporation

Parabon Nanolabs, Inc.

Vandalia Research, Inc.

Michael D Norton

Elizabeth E Murray

William John Walker, Jr

Wayne Douglas Brown

Richard D Begley

Lyle H Slack

Herbert Tesser

Derek A Gregg

Paul Valentine

Doreen D Edwards

Justin T Swick

Cathy Osborne

Chris Dwyer

Steven Armentrout

Derek Allen Gregg

Justin Thomas Swick

Hong Zhong

William Ian Towler

The present invention provides nanostructures that are particularly well suited for delivery of bioactive agents to organs, tissues, and cells of interest in vivo, and for diagnostic purposes. In exemplary embodiments, the nanostructures are complexes of DNA strands having fully defined nucleotide sequences that hybridize to each other in such a way as to provide a pre-designed three dimensional structure with binding sites for targeting molecules and bioactive agents. The nanostructures are of a pre-designed finite length and have a pre-defined three dimensional structure.

Finite fully addressable nucleic acid nanostructures as nanocarriers for delivery of pharmaceuticals

A thermal cycle system and method suitable for mass production of DNA comprising a temperature control body having at least two sectors. Each sector has at least one heater, cooler, or other means for changing temperature. A path traverses the sectors in a cyclical fashion. In use, a piece of tubing or other means for conveying is placed along the path and a reaction mixture is pumped or otherwise moved along the path such that the reaction mixture is repetitively heated or cooled to varying temperatures as the reaction mixture cyclically traverses the sectors. The reaction mixture thereby reacts to form a product. In particular, polymerase chain reaction reactants may continuously be pumped through the tubing to amplify DNA. The temperature control body is preferably a single aluminum cylinder with a grooved channel circling around its exterior surface, and preferably has wedge-shaped or pie-shaped sectors separated by a thermal barrier.

Apparatus and method for a continuous rapid thermal cycle system

Disclosed herein is an efficient, high speed production scale synthesis method for high molecular weight organic substances, such as DNA. The invention includes a method of conducting a polymerase chain reaction which comprises transporting a liquid through polymeric tubing disposed through a first reaction cycle region and at least a second reaction cycle region, each of which regions comprises at least a first and a second temperature zone, the temperature in each zone of said at least second region being substantially identical to the corresponding first and second zones in said first region, wherein said liquid is an aqueous solution comprising polymerase chain reaction reactants and a surface absorbing polymer.

Method for a continuous rapid thermal cycle system

A light-emitting ceramic based panel, hereafter termed 'electroceramescent' panel, is herein claimed. The electroceramescent panel is formed on a substrate providing mechanical support as well as serving as the base electrode for the device. One or more semiconductive ceramic layers directly overlay the substrate, and electrical conductivity and ionic diffusion are controlled. Light emitting regions overlay the semiconductive ceramic layers, and said regions consist sequentially of a layer of a ceramic insulation layer and an electroluminescent layer, comprised of doped phosphors or the equivalent. One or more conductive top electrode layers having optically transmissive areas overlay the light emitting regions, and a multi-layered top barrier cover comprising one or more optically transmissive non-combustible insulation layers overlay said top electrode regions.

Light emitting ceramic device

A striking implement, such as a maul, to reduce the impact force on the handle used with the member. The device is fabricated of metal and has two elongated parallel supports, a base, and a two angled end portions joining together one end of each parallel support, the interior of the device being hollow. Preferably, the device is formed integral with the head of the member, the handle extending through the device and being secured to the head member.

Handle saver

A light-emitting ceramic based panel, hereafter termed &ldquo;electroceramescent&rdquo; panel, and alternative methods of fabrication for the same are claimed. The electroceramescent panel is formed on a substrate providing mechanical support as well as serving as the base electrode for the device. One or more semiconductive ceramic layers directly overlay the substrate, and electrical conductivity and ionic diffusion are controlled. Light emitting regions overlay the semiconductive ceramic layers, and said regions consist sequentially of a layer of a ceramic insulation layer and an electroluminescent layer, comprised of doped phosphors or the equivalent. One or more conductive top electrode layers having optically transmissive areas overlay the light emitting regions, and a multi-layered top barrier cover comprising one or more optically transmissive non-combustible insulation layers overlay said top electrode regions.

Light emitting ceramic device and method for fabricating the same

Growing community of inventors

Shasta Lake City, CA, United States of America

Michael D Norton