Warner-lambert Company

Michael D Mullican

David T Connor

Paul C Unangst

Catherine R Kostlan

Roderick J Sorenson

Daniel L Flynn

Michael William Wilson

Gary P Shrum

Wiaczeslaw A Cetenko

David O Thueson

Bruce D Roth

Jagadish C Sircar

David Christopher Horwell

Bharat Kalidas Trivedi

James Bernard Kramer

Diane H Boschelli

Martyn C Pritchard

Bradley Dean Tait

Edward Roberts

Reginald S Richardson

Ann Holmes

Corinne E Augelli-Szafran

Julian Aranda

Uwe Trostmann

Hans-Jurgen Betche

The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.

3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and

Novel unnatural dipeptoids useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. The compounds are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, and opioids. The compounds are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.

Amino acid analogs as CCK antagonists

The novel 3,5-ditertiarybutyl-4-hydroxyphenylthio-1,3,4-thiadiazoles and oxadiazoles and 3,5-ditertiarybutyl-4-hydroxyphenylmethanone-1,3,4-thiadiazoles and oxadiazoles and related compounds of the present invention are antiinflammatory agents having activity as inhibitors of 5-lipoxygenase, cyclooxygenase or both.

3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles

Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome. The benzothiophenes of the present invention are particularly 2-tetrazolylcarboxamides of the benzothiophenes.

Method for treating acute respirator distress syndrome

Benzofurans and benzothiophenes having antiallergic activity and method

The present invention is for compounds having the formula of N-1H-tetrazol-5-yl-2-thiophenecarboxamides, N-1H-tetrazol-5-yl-2-pyrrolecarboxamides, N-1H-tetrazol-5-yl-2-furancarboxamides or analogs of each of the carboxamides. The compounds are useful for the treatment of allergic or inflammatory conditions or diseases. Thus, pharmaceutical compositions and methods of use are also the invention. Processes of preparation for the compounds are also the invention.

Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides

The present invention is novel 2-isopropoxy-N-1H-tetrazol-5-yl-benzamides having unexpected inhibition of histamine release from human basophils.

N-1H-tetrazol-5-ylbenzamides having use as antiallergy and

N-1H-tetrazol-5-yl-2-thiophene carboxamides,

Growing community of inventors

Ypsilanti, MI, United States of America

Michael D Mullican