University of Colorado

Cargill Inc.

Other

Opx Biotechnologies, Inc.

Michael D Lynch

Ryan T Gill

Tanya E W Lipscomb

Hans H Liao

Eileen Spindler

Tanya Warnecke

Ron Evans

Wendy Kathleen Ribble

Michael Tai Man Louie

Brittany Robinson

Shelley Copley

Matthew Lipscomb

Brittany Prather

Michael Louie

Tanya Lipscomb-Warnecke

Christopher P Mercogliano

Gill Ryan T

David Hogsett

Joseph R Warner

Tanya Ew Lipscomb

Tanya Warnecke-Lipscomb

Travis Wolter

Amar Singh

Ashley D Trahan

This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a fatty acid or fatty acid derived product, wherein the modified microorganism produces fatty acyl-CoA intermediates via a malonyl-CoA dependent but malonyl-ACP independent mechanism.

Microorganisms and methods for the production of fatty acids and fatty acid derived products

This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.

Method for producing 3-hydroxypropionic acid and other products

Methods for producing 3-hydroxypropionic acid and other products

Microorganism compositions are described that comprise combinations of genetic modifications that include a genetic modification to increase oxaloacetate alpha-decarboxylase enzymatic activity. By such genetic modification a 3-hydroxypropionic acid ('3-HP') production pathway is provided or improved. In various embodiments, comprising other genetic modifications, including selected gene disruptions, 3-HP production is greater than in a control microorganism lacking such combinations of genetic modifications.

Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase

Methods of obtaining mutant nucleic acid sequences that demonstrate elevated oxaloacetate &#x3b1;-decarboxylase activity are provided. Compositions, such as genetically modified microorganisms that comprise such mutant nucleic acid sequences, are described, as are methods to obtain the same.

Compositions and methods for 3-hydroxypropionate bio-production from biomass

The present disclosure concerns methods and compositions relating to mixed-library parallel gene trait mapping. In particular embodiments, the methods concern quantitative microarray hybridization techniques for genome-wide identification of trait conferring genes. In other embodiments, the compositions concern genetic elements that confer or are associated with a trait. In an exemplary embodiment, the trait is enhanced growth rate. In another exemplary embodiment, genetic elements that confer enhanced bacterial growth rate comprise part or all of the sequences of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4 or SEQ ID NO:5. In other embodiments, the genetic elements that confer enhanced bacterial growth rate correspond to the YliF, adrA, yeaP, yddV or ydeH genes of

Mixed library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes

Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes

The present invention concerns methods and compositions for the construction of a series of stable vectors for genomic library construction useful in Gram negative species. In certain embodiments, the vectors contain the pBBR1 replicon, capable of to stable replication in a broad range of Gram negative species. In various embodiments, the plasmid vectors may also contain bidirectional, rho-independent transcriptional terminators flanking the multiple cloning site, which allows for greater insert stability, and thus, greater genomic representation. Each vector may vary in its selection marker region, mobilization function, and promoter used to express insert sequences. These vectors are of use in the screening of highly representational genomic libraries in a broad variety of Gram negative species.

Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria

Embodiments of the present invention provide methods and compositions for microorganisms having increased alcohol tolerance. In certain embodiments, methods for using such microorganisms, and methods for identifying gene or genetic regions responsible for increased alcohol tolerance are contemplated.

Enhanced alcohol tolerant microorganism and methods of use thereof

A bird guard comprising pivotally attached covers for conductors emanating from an insulator. The insulator is covered while maintaining the integrity of the insulator's dielectric properties. Prevention of contact with the conductor is accomplished by covering a portion of the conductor emanating in a first direction from an insulative support. Inadvertent exposure of the conductor emanating in the first direction is then prevented. A portion of the conductor proximate to the insulative support is covered. The afore mentioned technique is accomplished concurrently with maintaining the dielectric integrity of the insulative support

Method and apparatus for preventing undesired contact with electrical conductors

Method and apparatus for protecting wildlife from contact with an energized fuse assembly known as a 'cutout', also known as a 'disconnect'. The cutout is shrouded from above and three sides. One side is left open to facilitate installation or removal of a fuse holder assembly. The shroud is formed to allow the use of a hot-stick for installation and removal of a fuse holder assembly into a fuse receptacle formed by upper and lower contact assemblies held in opposition to each other by an insulator. The shroud provides a slot enabling installation when a wire is connected to the upper contact assembly. A pin is used to hold the shrouding in place.

Method and apparatus for protection of wildlife from contact with power phase cutout mechanism

Growing community of inventors

Boulder, CO, United States of America

Michael D Lynch