Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Cv6 Therapeutics (ni) Limited

Michael D Lewis

Lynn D Hawkins

Sally T Ishizaka

Jeffrey Rose

James J Kowalczyk

Ana Maria Garcia

Daniel P Rossignol

Hu Yang

Pamela McGuiness

Pamela McGuinness

Mark Spyvee

Ieharu Hishinuma

Takeshi Nagasu

Kentaro Yoshimatsu

William J Christ

Ronald G Thurman

Eric Schwartz

Rulin Fan

Edmund M Harrington

Amy E Christuk

Xiaoning C Sheng

Anneliese Nault

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

6-membered uracil isosteres

The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.

Immunomodulatory compounds and methods of use thereof

Immunological adjuvant compounds compositions and methods of use thereof

Provided are novel peptidomimetic isoprenyl transferase inhibitors, methods for synthesizing such inhibitors, and methods for the use of such inhibitors for the treatment of tumors.

Inhibitors of isoprenyl transferase

Immunological adjuvant compounds, compositions, and methods of use thereof

Peptidomimetic isoprenyl transferase inhibitors R6SCHR1&prime;CHR1WCHR2YC(:X)NR3CHR5COR4 wherein R1&equals;OH, H, alkyl, amino group or R1 and R6 together form a heterocyclic ring; R1&prime;&equals;H, alkyl, aryl; R2&equals;H, alkyl, arylalkyl, heteroarylalkyl; R3&equals;H, alkyl, arylalkyl; R4&equals;OH, alkoxy, amino group; R5&equals;natural amino acid residue or D&mdash;E&mdash;F, where D is alkyl or alkenyl, E is O, S, N, or null, F is H, alkyl, aryl, carboxy amino, etc.; R6&equals;H, alkyl, acyl, etc.; W&equals;alkyl, alkenyl; X&equals;O, S, Y is M&mdash;O&mdash;P, where M is C0-6 alkyl, O is oxygen-C0-4 alkyl, P is(un)substituted C6-20 aryl are disclosed.

A method for the inhibition and amelioration of alcholic liver disease in a mammal in need of such treatment by administering novel analogs of Lipid A which act as endotoxin antagonists. These antagonists compounds are found to inhibit the swift increase in alcohol metabolism which typically accompanies ingestion of alcohol and which may lead to the pathophysiological abnormalities associated with alcoholic liver disease.

Method for treating alcoholic liver disease

Isoprenyl transferase inhibitors

A new and distinct variety of peach tree denominated varietally as 'Early Elegant Lady' and which is somewhat similar to the Elegant Lady Peach Tree (U.S. Plant Pat. No. 4,399) with which it is most closely related but which is distinguished therefrom and characterized as to novelty by producing fruit which are mature for commercial harvesting and shipment approximately June 22 through July 1 in Fresno County, Calif., the subject variety maturing for commercial harvesting and shipment approximately seven days earlier than that of the Elegant Lady Peach Tree.

Peach tree, 'Early Elegant Lady'

Growing community of inventors

Andover, MA, United States of America

Michael D Lewis