University of California

Polares Medical Inc.

Atritech, Inc.

Atrionix, Inc.

Ev3 Sunnyvale, Inc.

Appriva Medical, Inc.

Other

Middle Peak Medical, Inc.

Evera Medical, Inc.

Ev3 Santa Rosa, Inc.

Edwards Lifesciences Ag

Edwards Lifesciences Corporation

Emory University

Ev3 Inc.

Ev3 Endovascular, Inc.

Michael D Lesh

Erik Van Der Burg

Andrew G C Frazier

Chad C Roue

Alexander K Khairkhahan

Jonathan Jason Langberg

James Clayton Peacock, Iii

Mark A Maguire

Edward L Carcamo

Alan Klenk

Dino De Cicco

Alex Khairkhahan

Alan K Schaer

Marc S Kreidler

Kevin Jude Taylor

Michael R Ross

Michael Peter Ross

Martin F O'Sullivan

Guillermo P Picazo

Marc S Kriedler

Alex K Khairkahan

Zaya Tun

Danielle Tene

Stuart D Edwards

Craig E Mar

Stewart M Kume

Chris J Diederich

Darrell H Ogi

Dino DeCicco

David K Swanson

Dorin Panescu

James G Whayne

Randall T Lashinski

Jerome D Jackson

Thomas F Kordis

Matthew J Birdsall

Patrick M Owens

Randall J Lee

Arne Sippens Groenewegen

Michael D Mlynash

Randy Kesten

James C Peakcock, Iii

Paul R Steiner

Alex K Khairkhahan

James C Peacock

Martin F O'sullivan

Erik Van Der Berg

Craig Mar

Alan R Klenk

Tene Danielle

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

Systems and methods for anchoring an implant

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance devices for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, and one or more of the following: transseptal sheath, anchor delivery catheter, implant delivery catheter, and clip delivery catheter; and methods for transcatheter implantation of a coaptation element across a heart valve.

Systems and methods for transcatheter treatment of valve regurgitation

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation enhancement element for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, catheter and driver; and a method for transcatheter implantation of a coaptation element across a heart valve.

Device, system, and method for transcatheter treatment of valve regurgitation

Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

Coaptation enhancement implant, system, and method

The invention relates in some aspects to a device for use in the transcatheter treatment of mitral valve regurgitation, including steerable guidewires, implantable coaptation assistance devices, anchoring systems for attaching a ventricular projection of an implantable coaptation device, a kit, and methods of using an implantable coaptation assistance device among other methods.

Mitral valve implants for the treatment of valvular regurgitation

Growing community of inventors

Mill Valley, CA, United States of America

Michael D Lesh