Creare, Incorporated

Michael D Jaeger

Nabil A Elkouh

Mark C Bagley

Sandra J Graveson

Stephen Luckowski

Roger W Hill

Robert T Payne

A pneumatic autoinjector that, once activated, automatically mixes at least two components in a pre-filled chamber and then ejects the mixture in a manner suitable for medicament injection. The mixable components may be a dry/wet combination (e.g., powder and solvent), wet/wet combination (e.g., two pre-diluted medicaments), wet/gas combination (e.g., chemical A and gas B), or gas/gas combination. In some embodiments, autoinjectors made in accordance with the teachings of the present disclosure may automatically perform a sequence comprising thorough medicament mixing (e.g., reconstitution of a dried medicament with solvent), an optional pause to enhance medicament dissolution or suspension, optional needle insertion into the patient (not required in needle-free embodiments), medicament injection into the patient, and optional needle retraction for safe storage.

Pneumatic autoinjector with automated mixing

A method and structure for welding an air-sensitive metal, such as titanium, in an ambient environment containing air. The method () includes forming a weld () through a weld-through coating () applied to the weld face(s) () and heat-affected zone () of one or more workpiece(s) () to be welded. The weld-through coating may contain a reactive material that comprises one or more halogenides of alkali metal, e.g., fluorides of barium, calcium, and strontium. The weld-through coating may be applied to the workpiece using a thermal-spray process, such as a plasma-spray process (), prior to forming the weld. The weld-through coating may be applied to the workpiece(s) generally contemporaneously with the formation of the weld just ahead of the weld or may be applied at any time prior to forming the weld.

Method and structure for welding an air-sensitive metal in air

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Plainfield, NH, United States of America

Michael D Jaeger