Bristol-myers Squibb Compnay

Bristol-myers Company

Michael D Helman

Thomas A Re

Ronald R Rafft

Leonard Mackles

F Christopher Zusi

Alison B Lukacsko

The present invention provides for a composition containing a pharmacologically active agent and a selected imidazole or an imidazole derivative, such composition exhibiting enhanced penetration of the pharmacologically active agent component when a composition containing the aforementioned components is applied to skin. A method of enhancing dermal penetration of compositions containing a pharmacologically active agent is also provided.

Method for enhancing transdermal penetration and compositions useful

Perspiration is decreased in an area of the skin subject to perspiration by applying to such area an antiperspirant amount of an imidazole derivative of the formula I ##STR1## wherein X is O or S and Y is Cl or H, or a dermatologically acceptable salt thereof, preferably in a dermatologically acceptable compatible vehicle.

Antiperspirant process and imdazole containing compositions utilizable

A topical antiperspirant composition containing an antihistamine selected from the group consisting of antazoline, pyrilamine, tripelennamine, diphenhydramine, phenindamine and their corresponding pharmaceutically acceptable salts and an enhancer for said antihistamine selected from the group consisting of sodium sulfate, glutamic acid; octyl palmitate and propylene glycol methyl ether.

Antiperspirant compositions, containing certain antihistamines and

An antiperspirant process and composition wherein the active antiperspirant ingredient is an alpha adrenergic amine that has at least a substantial alpha.sub.2 adrenergic amine activity component.

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Edison, NJ, United States of America

Michael D Helman