Janssen Pharmaceutica Nv

Michael D Hack

Alec D Lebsack

Kelly J McClure

Natalie Anne Hawryluk

Wendy Eccles

Paul J Krawczuk

Mark D Rosen

William Moore Jones

Steven P Meduna

John M Keith

Jing Liu

Brett D Allison

Anne E Fitzgerald

James Patrick Edwards

J Guy Breitenbucher

Jennifer Diane Venable

Daniel J Pippel

Laurent Gomez

David E Kindrachuk

Neelakandha S Mani

Alice Lee-Dutra

Clark A Sehon

Cheryl A Grice

Hariharan Venkatesan

Steven D Goldberg

John J M Wiener

Genesis M Bacani

Kimberly Schwarz

Zachary S Sales

Liu Y Tang

Ronald L Wolin

Daniel J Buzard

Liming Huang

Michael H Rabinowitz

Bryan James Branstetter

Victor K Phuong

Jeffrey E Merit

Karen Joy Shaw

Nigel P Shankley

Alexander Raymond Rovira

S Timothy Motley

Terrance D Barrett

Magda F Morton

Brian J Morrow

Kevin Douglas Kreutter

Wenying Chai

James Breitenbucher

Kristen L Arienti

J Kent Barbay

Aaron T Herrmann

Kelly J Mcclure

Natalie A Hawryluk

Alexander R Rovira

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

Small molecule inhibitors of NF-kB inducing kinase

Small molecule inhibitors of NF-&#x3ba;B inducing kinase

The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R, L and Rare as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention. 

Flap modulators

The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R, L and Rare as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R, R, R, R', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

FLAP modulators

The present invention relates to compounds of Formula (I), or a form thereof wherein ring A, R, R, R, R', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention. 

Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.

Tetrahydro-pyrimidoazepines as modulators of TRPV1

Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

Bicyclic pyrazole compounds as antibacterial agents

Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating Hreceptor, and in treating conditions such as inflammation, Hreceptor-mediated conditions, and related conditions.

Benzoimidazole compounds

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San Diego, CA, United States of America

Michael D Hack