Cardiovascular Dynamics, Inc.

Radiance Medical Systems, Inc.

Endologix, Inc.

Adiance Medical Systems, Inc.

Other

Michael D Crocker

Lynn M Shimada

Robert John Elicker

Mark Anthony Siminuk

George F Kick

Muny Chum

Michael R Henson

Brett A Trauthen

Lisa A Tam

Cheryl C Hull

Robert Fazio

Claire Walker

Edward F Smith

John McB Hodgson

Girma Kebede

Gary Strathern

Gregg Stone

Disclosed is a focal balloon having at least one reference zone and a focal zone. In one embodiment, the reference zone and focal zone are inflatable to a first generally cylindrical profile at a first pressure. At a second, greater pressure, the focal section expands to a second, greater diameter, while the reference zone remains substantially at the first diameter. In an alternate embodiment, the focal zone and the reference zone are inflatable to their respective predetermined diameters at the inflation pressure, in the absence of constricting lesions or anatomical structures. Multiple lobed and drug delivery embodiments are also disclosed.

Focalized stent implantation

Disclosed is a balloon catheter having an inflatable balloon having a radiation carrier such as a radiation delivery layer thereon. In one embodiment, the radiation delivery layer comprises one or more layers of metal foil, such as gold. The foil is irradiated, and the balloon is thereafter positioned at a treatment site in a vessel and expanded to bring the metal foil layer into close proximity with the vessel wall. In another embodiment, the radiation carrier is in the form of a dopant in the balloon material. Methods of using the balloon include radiation dosing a site following a balloon dilatation or other procedure, and simultaneously performing balloon angioplasty and radiation dosing.

Radiation delivery balloon catheter

Disclosed are sources and methods for delivering a radioactive dose to a site in a body lumen. The sources are preferably mounted on a balloon or other expandable or deployable mechanical structure. The source and methods enable delivery of a clinically significant dose of radiation into a vessel wall in a relatively short time while using a relatively low activity. The sources also enable delivery of a substantially uniform dose into the vessel wall, whether or not such delivery is through the wall of a stent.

Radiation delivery catheters and dosimetry methods

Disclosed is a focal balloon having at least one reference zone and a focal zone. In one embodiment, the reference zone and focal zone are inflatable to a first generally cylindrical profile at a first pressure. At a second, greater pressure, the focal section expands to a second, greater diameter, while the reference zone remains substantially at the first diameter. In an alternate embodiment, the focal zone and the reference zone are inflatable to their respective predetermined diameters at the inflation pressure, in the absence of constricting lesions or anatomical structures. Multiple lobed and drug delivery, embodiments are also disclosed.

Focalized intraluminal balloons

Disclosed is a focal balloon having at least one reference zone and a focal zone. In one embodiment, the reference zone and focal zone are inflatable to a first generally cylindrical profile at a first pressure. At a second, greater pressure, the focal section expands to a second, greater diameter, while the reference zone remains substantially at the first diameter. In an alternate embodiment, the focal zone and the reference zone are inflatable to their respective predetermined diameters at the inflation pressure, in the absence of constricting lesions or anatomical structures. Both balloons may be utilized to conduct interactive angioplasty to provide real-time feedback about the morphology of the lesion, and both balloons may be utilized to implant or size intravascular stents.

Fixed focal balloon for interactive angioplasty and stent implantation

A dilatation catheter includes an inflation balloon having a variable diameter inflation profile. The balloon has a first inflation profile, in which it exhibits a substantially cylindrical central working profile. The first inflation profile of the balloon is achieved by inflating the balloon to a first inflation pressure. The balloon has a second inflation profile which is achieved by increasing the inflation pressure to a second, higher pressure. In the second inflation profile, a proximal segment and a distal segment of the balloon have a first inflated diameter and a central focal segment, separating the proximal and distal segments, has a second inflated diameter, such that the second inflated diameter is greater than the first inflated diameter. Methods of using the catheter are also disclosed.

Interactive angioplasty

Disclosed is a low profile infusion catheter for medical use. The catheter comprises a proximal infusion lumen, which, in one embodiment, branches into two or more distal infusion lumen. Each of the distal fluid lumen is provided with at least one effluent flow port for infusion into the patient. Construction of the catheter provides a series of discrete flexibility zones.

Low profile infusion catheter

An expandable intraluminal stent having a tubular shaped member having first and second ends defining an axial passageway therethrough. The tubular shaped member has a multiplicity of slots helically formed thereabout that are preferably provided in rows wherein the slots of each row are arranged in an end to end fashion. The tubular shaped member is initially disposable in a radially collapsed configuration such that the device may be passed into the lumen of a blood vessel, and subsequently expand to an operative configuration wherein it will frictionally engage the surrounding blood vessel wall to hold the device in fixed position within the blood vessel lumen. In an alternative embodiment, the stent is designed to accommodate a bifurcated vessel having a collateral vessel extending therefrom.

Coronary stent and method of fabricating same

Disclosed is a tuvular sheath which is adapted to fit coaxially over an inflatable balloon. The sheath functions to alter the expansion characteristics of the balloon. In one preferred embodiment, the sheath converts the inflation profile of a dilatation balloon from a compliant mode to a noncompliant mode. Advantageously, the balloon sheath may be used in stent placement procedures, to accurately size the stent within a body lumen, while providing protection against balloon rupture. In one embodiment, the balloon sheath comprises a two-layered tubular structure, with an outer elastic layer surrounding an inner inelastic layer. Also disclosed are methods of altering the expansion characteristics of a balloon using the balloon sheath.

Balloon sheath

Radiation delivery balloon

Disclosed is a Low Profile Perfusion Catheter, for use in coronary angioplasty applications. Preferably, the catheter is provided with an inflatable dilatation balloon, and a perfusion lumen extending therethrough. The diameter of the perfusion lumen is enlargable from a first, reduced diameter to a second, enlarged diameter. In one embodiment, an axially movable tubular support is movable within the lumen from a proximal, insertion position to a distal perfusion position. In another embodiment, the support is radially expandable. In a further embodiment, a porus drug delivery balloon is provided.

Growing community of inventors

Mission Viejo, CA, United States of America

Michael D Crocker