Marshfield Clinic Health System, Inc.

Michael D Caldwell

David E Lewis

A composition is provided that, when utilized in combination with warfarin, greatly improves the anticoagulant effects of warfarin in mammalian subjects. The composition is a compound having a naphthohydroquinone ring system substantially similar to the ring system of the reduced form of vitamin Kand has the general formula: where Rand Rare hydrogen or acyl, Ris a saturated or unsaturated alkyl group with up to 6 carbons, and Ris a saturated or unsaturated alkyl group with up to 20 carbons, or Rand Rare part of a cyclic or polycyclic ring system.

Growing community of inventors

Milladore, WI, United States of America

Michael D Caldwell