Xenogen Corporation

Matrix Sensors, Inc.

Michael D Cable

Bradley W Rice

David G Nilson

Daniel G Stearns

Michael Bo Nelson

Kevin Kearney

David N Sprague

Christopher A Rasco

Matthias Steiert

Olivier Coquoz

Rick Dalgetty

Matthew P Presta

Steven Yamamoto

Matthew D Hern

Heinrich Sussner

Chaincy Kuo

Barton V Beeman

Mike R Massucco

Binoy Mirvar

Brian Roberts Bates

Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A first sensor in the array includes a first resonating member having a first surface comprising a receptor material coated over a first underlying material. A second sensor includes a second resonating member having a second surface comprising the receptor material coated over a second underlying material that is different than the first underlying material. The first underlying material, the second underlying material, and the receptor material are selected such that the first resonating member, having a combination of the receptor material and the first underlying material, has a different ability to adsorb or bind a mass of one or more analytes than does the second resonating member having a combination of the receptor material with the second underlying material. Methods for fabricating sensors with surface modifications are also provided.

Array of sensors with surface modifications

The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.

Multi-mode internal imaging

The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.

Method and apparatus for 3-D imaging of internal light sources

A graphical user interface is provided which allows the user to perform numerous operations suitable for analysis of in-vivo images within a single display screen or a single window. Using the in-vivo GUI, the user may create and manipulate analysis tools such as rectangle and ellipse tools to define regions of interest and perform various measurements on an in-vivo image. In addition, the GUI allows the user to store measurement results in a dated electronic notebook, display testing information, manipulate image presentation and print while maintaining view of the image.

Graphical user interface for in-vivo imaging

A method for analyzing liquid samples may comprise applying a liquid to a cMUT device having a plurality of sensors, drying the plurality of sensors, electronically detecting an agent bound to each of the plurality of sensors, wherein the electrical circuit provides a sensor output responsive to a mechanical resonance frequency of the sensor, wherein the mechanical resonance frequency of the sensor is responsive to the binding of an agent to the functionalized membrane, and determining the mass of the agent bound to each of the plurality of sensors.

Liquid analysis using capacitative micromachined ultrasound transducers

The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.

Structured light imaging apparatus

An imaging box assembly is provided for capturing an image of a sample. The imaging box assembly includes a body having an interior cavity for receiving the sample, and having a front portion defining an opening into the cavity. The body further includes a view port enabling viewing of the sample contained in the interior cavity. A door is mounted to the body that is movable between an opened condition, enabling access to the interior cavity through the cavity opening, and a closed condition, positioning a door rear portion substantially adjacent the body front portion to prevent access through the cavity opening. The box assembly further includes a moveable stage disposed in the cavity interior that supports the sample. The moveable stage is adapted to selectively position the sample at a selected one of a plurality of positions relative to the view hole.

Imaging apparatus with selectable moveable stage

The invention described herein provides systems and methods for handling objects within an imaging system, such as a multi-modal imaging system. An object handling system operates to position an object to be imaged in an interior cavity of a light imaging system, and also moves the object to be imaged between the light imaging system and a second imaging system. The object handling system can include components such as a stage that supports the object, a manipulator configured to move the stage between the interior and exterior of the light imaging system and a light seal configured to interface with a light seal on an exterior wall of the light imaging system.

Imaging system including an object handling system

3-D in-vivo imaging and topography using structured light

The invention describes systems and methods to obtain and present imaging data in absolute units. The systems and methods convert relative image data produced by a camera to absolute light intensity data using a compensation factor. The compensation factor accommodates for hardware and specific imaging conditions in the imaging system that variably affect camera output. The present invention determines the compensation factor based on assessing the output of the camera against a known light source for a specific set of imaging conditions in the imaging system. The compensation factor is then stored in memory corresponding to the specific set of imaging conditions. Upon subsequent imaging with the set of imaging conditions, the corresponding compensation factor is called from memory and applied to the camera output. A compensation factor may be determined and stored for each hardware state and imaging condition available to the imaging system.

Growing community of inventors

Danville, CA, United States of America

Michael D Cable