Ortho Regenerative Technologies Inc.

Polyvalor, Limited Partnership

Ecole Polytechnique

Piramal Healthcare (canada) Ltd.

Bio Syntech

Biosyntech Canada, Inc.

Michael D Buschmann

Abdellatif Chenite

Caroline Hoemann

Pierre Savard

Anik Chevrier

Marc D McKee

Martin Garon

Marc Lavertu

Daniel Veilleux

John A Hardin

Wei Ouyang

Matthieu Ouellet

Pierre Le Guyader

Robert Guardo

Abderrazzak Merzouki

Caroline D Hoemann

John Hardin

Alessio Serriqi

Jun Sun

Marc D Mckee

The present application relates to a lyophilized scaffold composition having at least one polysaccharide wherein said scaffold is substantially solid and capable of being formed into a desired shape; wherein the at least one polysaccharide has a protonation level resulting in controlled rehydration of said scaffold, such that when said scaffold is contacted with at least one of a neutral aqueous solution, blood, blood derived fluid and combinations thereof, said scaffold forms a microparticle dispersion and stimulates tissue remodeling and anabolic wound repair, a process for preparing a lyophilized scaffold composition and the use of a lyophilized scaffold composition for wound repair in a mammal.

Lyophilized polymer scaffold compositions, processes for preparation and use in anabolic wound repair

The present application relates to a freeze-dried polymer composition containing chitosan and at least one lyoprotectant, a process for preparing a freeze-dried composition containing chitosan and at least one lyoprotectant and the use of a reconstituted freeze-dried chitosan composition to prepare implants for tissue repair.

Freeze-dried polymer compositions for mixing with platelet rich plasma to form implants for tissue repair and/or compositions for therapeutic intra-articular injections

There is disclosed a composition and a method for the efficient delivery of a therapeutic RNAi-inducing nucleic acid to cells both in vitro and in vivo through specific formulations of a non viral delivery system using chitosans. Particularly, the composition contains a nucleic acid and a specific chitosan that has the following physico-chemical properties: a number-average molecular weight between 5 kDa and 200 kDa, a degree of deacetylation between 80% and 95% and a chitosan amine to nucleic acid phosphate ratio below 20.

Compositions and methods for efficacious and safe delivery of siRNA using specific chitosan-based nanocomplexes

The present disclosure relates to an activated polymer composition for use in repairing tissue of a patient comprising platelet-rich plasma (PRP), a chitosan solution, a salt such as NaCI or glycerol phosphate, and an activator such as at least one of CaCIand a mixture of thrombin/CaCI.

Soluble physiological chitosan formulations combined with platelet-rich plasma (PRP) for tissue repair

There is described a method for non-invasively measuring electrical activity in a joint of a subject, the method comprising: removably attaching in a non-invasive manner at least two electrodes to a skin surface around an articulation comprising the joint; generating electroarthrographic potentials within the joint by loading the articulation; capturing the electroarthrographic potentials using the at least two electrodes; discriminating between electroarthrographic potentials originating from joint tissue activity and those from other sources; and generating measurement signals representing the electrical activity of joint tissue.

Non-invasive measuring of load-induced electric potentials in diarthroidial joints

The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere to the tissue and promote support for cell proliferation for repairing the tissue. Other than a polymer, the composition preferably comprises a blood component such as whole blood, processed blood, venous blood, arterial blood, blood from bone, blood from bone-marrow, bone marrow, umbilical cord blood, placenta blood, erythrocytes, leukocytes, monocytes, platelets, fibrinogen, thrombin and platelet rich plasma. The present invention also relates to a new composition to be used with the method of the present invention.

Composition and method for the repair and regeneration of cartilage and other tissues

A universal material testing device which includes a frame; an actuator mounted on the frame for controlling a displacement of a sample to be tested; a load cell movably mounted on the frame and adapted to abut against the sample for detecting a force applied thereon by the actuator, the load cell producing a signal corresponding to the force detected; a signal conditioning unit for reducing input noise and for processing of the signal and executing specific tests by coordination of displacement control and load signals received for processing from the load cell; and a detachable chamber with humidifying media for humidification of the sample environment confined within the chamber and separated frm the sample so as to avoid potential damaging effects of humidity on the sample or on the device. The device is useful for determining certain material properties of a sample.

Universal mechanical testing device

The present invention relates to a medical apparatus for the early detection and the diagnosis of cartilage degeneration and a method for using such apparatus. The apparatus comprises at least two point electrodes, a signal processor located in proximity of the electrodes, a defined abutment in recess of the electrodes for allowing compression of the cartilage against the electrodes until the cartilage abuts against the abutment surface and a computer program for analyzing and interpreting the data received from the electrodes. The medical apparatus may be used in research to identify effects of new compounds or drugs on the cartilage or may be used in clinics to monitor the degradation of cartilage of a patient over an extended period of time.

Medical apparatus for the diagnosis of cartilage degeneration via

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Montreal, Canada

Michael D Buschmann