Bayer Aktiengesellschaft

Bayer Corporation

Michael Conrad

Hilmar Bischoff

Delf Schmidt

Lutz Assmann

Joachim Schuhmacher

Rolf Angerbauer

Carsten Schmeck

Dietmar Bielefeldt

Gunter Schmidt

Klaus-Dieter Bremm

Heinz-Jurgen Wroblowsky

Paul Naab

Carl Casser

Arndt Brandes

Holger Paulsen

Henry Giera

Reinhard Lantzsch

Jurgen Stoltefuss

Matthias Muller-Gliemann

Alfons Grunenberg

Vijay C Desai

J&uuml;rgen Stoltefuss

Michael L&ouml;gers

Shekhar V Kulkarni

Dietrich Seidel

Matthias M&uuml;ller-Gliemann

Oliver Brehm

The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hypertipoproteinaemia and arteriosclerosis.

Cycloalkano-pyridines

The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The, cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hyperlipoproteinaemia and arteriosclerosis.

A novel process for the preparation of 2-chloro-benzimidazole derivatives of the formula ##STR1## in which A represents optionally halogenated alkylene having 1 or 2 carbon atoms, which process comprises reaction 1,3-dihydro-benzimidazol(ethi)ones of the formula ##STR2## in which X represents oxygen or sulphur, with phosphorus oxychloride. Novel 1,3-dihydro-benzimidazol(ethi)ones of the formula(II) and process for their preparation.

Process for preparing 2-chloro-benzimidazole derivatives

A novel process for the preparation of 2-chloro-benzimidazole derivatives of the formula in which

Alkoxytriazolinones of the formula (I) �known for example as intermediates for preparing agrochemically active compounds! ##STR1## wherein R represents an alkyl group, an alkenyl group, an alkinyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group or an arylalkyl group, any of which may be substituted, are prepared by reacting

Process for preparing alkoxytriazolinones

The invention relates to the crystalline form of the hydrochloride of the compound (R)-(-)-2-{N-�4-(1,1-dioxido-3-oxo-2,3-dihydro-benzisothiazol-2-yl)-butyl! -aminomethyl}-chroman, which is present as a stable form at room temperature. The crystalline modification V of the hydrochloride is suitable in particular for the preparation of solid medicaments, in particular of medicaments for the treatment of neuronal degenerations.

Crystalline hydrochloride of

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Wuppertal, Germany

Michael Conrad