Zeneca Limited

Michael Charles Standen

Raymond Vincent Jones

David John Ritchie

Paul A Worthington

Nigel Hall

Alfred Glyn Williams

Alan John Whitton

Ewan Campbell Boyd

Gordon Richard Munns

Nicholas Russell Foster

Peter Karl Wehrenberg

Richard John Whitby

Jane Louise Bell

Hannah Sallie McCann

David Alan Glanville

Julie Forrester

Graham A Rae

Timothy John Doyle

Nicholas Charles Evens

4,6-Dichloropyrimidine is prepared by treating 4,6-dihydroxypyrimidine with a chlorinating agent of the formula R.sup.1 R.sup.2 R.sup.3 PCl.sub.2 wherein R.sup.1, R.sup.2 and R.sup.3 are independently alkyl or aryl, or one or more of the groups R.sup.1, R.sup.2 and R.sup.3 is linked to a polymer support. Conveniently, the chlorinating agent may be prepared in situ by reacting the corresponding phosphine oxide with phosgene. Thus, in a preferred process, 4,6-dichloropyrimidine is prepared by treating 4,6-dihydroxypyrimidine with phosgene in the presence of a phosphine oxide.

Chemical process

One-step process for preparing methyl 2-(halomethyl)phenylacetate from

Process for the preparation of 2-(6-substituted pyrid-2-yloxymethyl)

Process for preparing 3-isochromanone

Chiral organometallic compounds

Process for the preparation of benzophenthiones and benzophenones

Process for the manufacture of N-phosphonomethyliminodiacetic acid

A process for the preparation of a polycyclic dye of Formula (1): ##STR1## by reacting a compound of Formula (2): ##STR2## with a benzofuranone of Formula (3): ##STR3## wherein: R.sup.1 and R.sup.2 each independently is --H or alkyl;

Preparation of polycyclic dyes

A process for the preparation of a compound of Formula (1): ##STR1## wherein: W.sup.1 is aryl;

Polycyclic dyes

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Clackmannan, United Kingdom

Michael Charles Standen